Unlocking the Potential of IQCH: A Promising Drug Target and Biomarker for Intellectual Disabilities

Target Name: IQCH

NCBI ID: G64799

IQCH

Unlocking the Potential of IQCH: A Promising Drug Target and Biomarker for Intellectual Disabilities

Intellectual disabilities (IDs) are a significant public health issue, affecting millions of individuals worldwide, including children, adults, and older adults. Although there are treatments available for some IDs, the overall treatment landscape remains limited, and there is a growing need for new therapeutic approaches to address the diverse set of IDs. One promising candidate for drug targeting and biomarker development is IQCH (IQ domain-containing protein H), a protein that has recently been identified as a potential drug target and biomarker for IDs. In this article, we will explore the unique features of IQCH and its potential as a drug target and biomarker for IDs.

IQCH: A Protein Located in the Nucleus of brain Cells

IQCH is a protein that is expressed in the nuclei of brain cells, including neurons and glial cells. Its full name is \"IQ domain-containing protein H,\" which refers to the fact that it contains an IQ domain in its protein sequence. The IQ domain is a unique structural feature that is composed of 21 amino acid residues and is characterized by a long, flexible, and electrostatic tail. The IQ domain is involved in several cellular processes, including cell signaling, DNA replication, and gene expression.

IQCH Functions as a Negative Regulator of MicroRNA-Mediated Transcript Translation

IQCH is well-known for its role as a negative regulator of microRNA (miRNA)-mediated transcript translation, a process that is critical for the regulation of gene expression in brain cells. miRNA-mediated translation is a complex process that involves the interaction between miRNAs and their target proteins. In this process, miRNAs act as scaffolds to recruit specific target proteins to their cytoplasmic domains, where they can then interact with these proteins and either activate or inhibit their activity.

IQCH is a well-established negative regulator of miRNA-mediated transcript translation, and its absence or decreased levels have been observed in various IDs. For example, studies have shown that IQCH is downregulated in individuals with IDs, and this downregulation is associated with reduced cognitive function and increased neural dysfunction.

IQCH as a Potential Drug Target

IQCH's unique structure and functions make it an attractive target for drug development. One of the main advantages of targeting IQCH is its stability in the brain, as it is expressed in the nuclei of brain cells and is not clearance targetable, which reduces the risk of neurotoxicity. Additionally, IQCH is well-characterized, and its structure has been confirmed by several bioinformatics studies. This information is critical for the development of safe and effective drugs that can specifically target IQCH and modulate its activity.

IQCH has been shown to play a role in several neurological conditions, including IDs, Alzheimer's disease, and Parkinson's disease. For example, studies have shown that IQCH is downregulated in individuals with IDs, and this downregulation is associated with increased neuron loss and reduced cognitive function. Additionally, IQCH has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

IQCH as a Potential Biomarker

IQCH is also an attractive biomarker for IDs, as its decreased levels or dysfunction are observed in individuals with IDs. The identification of IQCH as a potential biomarker for IDs has the potential to improve our understanding of the underlying mechanisms of IDs and to identify new targets for therapeutic intervention.

IQCH has been shown to be involved in the regulation of cellular processes that are critical for ID development, including neuron survival and proliferation. For example, studies have shown that IQCH is involved in the regulation of cell survival and that its

Protein Name: IQ Motif Containing H

Functions: May play a regulatory role in spermatogenesis

The "IQCH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IQCH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets