Discovering The Function of CYSLTR1: A Protein Playing A Crucial Role in The Nervous System

Target Name: CYSLTR1

NCBI ID: G10800

CYSLTR1

Discovering The Function of CYSLTR1: A Protein Playing A Crucial Role in The Nervous System

CYSLTR1 (CYSLT1R) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. Its name comes from its last amino acid residue, which is a type of leucine. CYSLTR1 is a glycoprotein whose sugar part is composed of 伪-helices and 尾-sheets. This protein is made up of four different amino acids, including leucine, glutamic acid, asparagine and glutamine. CYSLTR1 plays a variety of biological functions in cells, including participating in cell signaling, cell adhesion and cell migration.

CYSLTR1 was first discovered in 1995, when researchers used genetic engineering technology to construct a CYSLTR1 gene and introduced it into mouse embryonic stem cells. They found that after expressing the CYSLTR1 gene, these cells were able to exhibit neuron-like behaviors, including synapse formation and neuronal migration. This discovery aroused great interest among scientists because CYSLTR1 gene knockout mice develop various abnormalities in the nervous system.

Since then, scientists have studied the function of the CYSLTR1 gene through various means, including its expression, localization, and function in various biological processes. Studies have shown that CYSLTR1 plays an important role in the nervous system, especially in the growth of neurons, aspects of development and synaptogenesis.

CYSLTR1 gene knockout mice exhibit various abnormalities in the nervous system, including neuronal apoptosis, synaptic loss, neuronal migration disorders, and abnormal neuronal morphology. These abnormalities suggest that CYSLTR1 plays a crucial role in normal neuron function.

In addition, CYSLTR1 gene knockout mice also show other physiological and behavioral abnormalities, including reduced immune function, reduced metabolic rate, movement disorders, and abnormal social behavior. These abnormalities indicate that CYSLTR1 also plays an important role in regulating physiological functions.

Because CYSLTR1 plays an important role in both normal neuron function and pathophysiological processes, it is considered a potential drug target. Scientists are exploring CYSLTR1 as a drug target to treat various neurological diseases, including neurodegenerative diseases, neural tumors, and nerve injuries.

In addition, the CYSLTR1 gene is also used as a tool for many biological research, including gene knockout technology, proteomics and drug screening. CYSLTR1 gene knockout technology can be used to study the function and impact of the CYSLTR1 gene, as well as its interactions with other molecules. Proteomic technology can conduct in-depth research on the expression and function of the CYSLTR1 gene to understand the role of CYSLTR1 in the nervous system. Drug screening technology can be used to discover CYSLTR1 gene knockout drugs that can treat neurological diseases.

In summary, CYSLTR1 is a protein that plays an important role in the nervous system. Its functions and effects are being intensively studied, and CYSLTR1 gene knockout technology can be used to treat various neurological diseases. With the deepening of research, CYSLTR1 will become an important drug target and provide people with better treatments.

Protein Name: Cysteinyl Leukotriene Receptor 1

Functions: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4

The "CYSLTR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYSLTR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets