ADGRL1: A Potential Drug Target for Alzheimer's (G22859)

Target Name: ADGRL1

NCBI ID: G22859

ADGRL1

ADGRL1: A Potential Drug Target for Alzheimer's

ADGRL1 (Alzheimer's disease-related G protein-coupled receptor 1) is a protein that is expressed in the brain and is known to play a role in the development and progression of Alzheimer's disease (AD). The ADGRL1 protein is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a critical role in cellular signaling.

ADGRL1 is expressed in the brain and is involved in the regulation of a wide range of physiological processes, including memory, learning, and mood regulation. It is also involved in the regulation of the production of neurotransmitters, such as dopamine and glutamate, which are important for the functioning of the brain.

Recent studies have suggested that ADGRL1 may be a drug target or biomarker for the development and treatment of AD. For example, researchers have found that inhibiting the activity of ADGRL1 can improve memory and reduce the formation of neurofibrillary tangles in AD patients. Additionally, ADGRL1 has been shown to be overexpressed in the brains of individuals with AD, which may be a potential biomarker for the disease.

Another study found that ADGRL1 was overexpressed in the brains of individuals with AD, and that inhibiting the activity of the protein reduced the formation of neurofibrillary tangles in the brain. This suggests that ADGRL1 may be a useful target for the development and treatment of AD.

In addition to its potential as a drug target or biomarker, ADGRL1 is also of interest as a potential therapeutic approach for the treatment of other neurological disorders. For example, studies have suggested that ADGRL1 may be involved in the development and progression of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease.

Overall, ADGRL1 is a protein that is of great interest for the development and treatment of AD and other neurological disorders. Further research is needed to fully understand the role of ADGRL1 in these processes and to develop effective therapies based on the protein.

Protein Name: Adhesion G Protein-coupled Receptor L1

Functions: Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells (PubMed:35907405). Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)

The "ADGRL1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADGRL1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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