ADGRD1: A Potential Drug Target and Biomarker (G283383)

Target Name: ADGRD1

NCBI ID: G283383

ADGRD1

ADGRD1: A Potential Drug Target and Biomarker

ADGRD1 (Adhesion G-protein coupled receptor D1) is a transmembrane protein that plays a crucial role in cell-cell adhesion. It is a G protein-coupled receptor (GPCR), which means it consists of a extracellular domain that is connected to a intracellular domain that contains a catalytic active site and a transmembrane region. The D1 subunit of ADGRD1 is a 21-kDa protein that is expressed in many different tissues and cells in the body.

ADGRD1 is involved in many different processes in the body, including the regulation of cell adhesion, migration, and survival. It is highly expressed in various tissues, including the brain, pancreas, and gastrointestinal tract, and has been implicated in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Despite its widespread expression, the function of ADGRD1 is not well understood. Many researchers have studied its structure and biochemical properties, but the precise mechanism by which it functions remains a mystery.

One possible function of ADGRD1 is as a drug target or biomarker. Many diseases are caused by the failure of normal cell processes, and targeting ADGRD1 with drugs that can modulate its activity could be a promising new approach to therapy.

ADGRD1 as a Drug Target

ADGRD1 has been the focus of much research as a potential drug target. Studies have shown that modulating the activity of ADGRD1 can have a significant impact on the behavior of various cell types, including cancer cells, neurodegenerative cells, and immune cells.

One of the key compounds that have been shown to interact with ADGRD1 is the small molecule drug, U012652. U012652 is a potent inhibitor of ADGRD1 that has been shown to inhibit the activity of ADGRD1 in cell culture and in animal models of disease.

In addition to U012652, a number of other small molecules have also been shown to interact with ADGRD1. These molecules include natural products, such as the alkaloid, quercetin, and the amino acid, lysine. Other molecules that have been shown to interact with ADGRD1 include molecules that are known to modulate the activity of other GPCRs, such as the protein, tyrosine phosphatase 2 (TIP2), and the protein, FAK.

The precise mechanism by which these molecules interact with ADGRD1 is not well understood, but it is thought to involve a process called GPCR-mediated signaling. This involves the interaction of a GPCR with its ligand, which can activate a protein kinase or other signaling pathway.

ADGRD1 as a Biomarker

ADGRD1 has also been shown to be a potential biomarker for a number of diseases. For example, high levels of ADGRD1 have been detected in the brains of individuals with Alzheimer's disease, and levels of ADGRD1 have been shown to be elevated in the blood samples of individuals with cancer.

In addition to its potential as a drug target, ADGRD1 has also been shown to be a potential biomarker for a number of diseases. For example, high levels of ADGRD1 have been detected in the brains of individuals with Alzheimer's disease, and levels of ADGRD1 have been shown to be elevated in the blood samples of individuals with cancer.

One of the challenges in using ADGRD1 as a biomarker is the difficulty of accessing the sample site. The brain is a complex structure, and accessing the sample site can be a challenging task. Additionally, the expression of ADGRD1 is not always reliable, as levels of the protein can vary depending on the cell type and the environment.

Conclusion

ADGRD1 is a transmembrane protein that is involved in

Protein Name: Adhesion G Protein-coupled Receptor D1

Functions: Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701)

The "ADGRD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADGRD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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