ADGRE5: A Transmembrane Protein Targeted for Drug Development

Target Name: ADGRE5

NCBI ID: G976

ADGRE5

ADGRE5: A Transmembrane Protein Targeted for Drug Development

The Adhesion G protein-coupled receptor (ADGRE5) is a transmembrane protein that plays a crucial role in various physiological processes in the body. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a variety of roles in cellular signaling. While many GPCR proteins have been identified and studied, ADGRE5 is still an emerging drug target and biomarker.

Overview of ADGRE5

ADGRE5 is a 21-kDa protein that is expressed in various tissues and cells in the body. It is primarily localized to the plasma membrane of cells and plays a role in cell signaling, specifically in the regulation of cell adhesion. ADGRE5 is a GPCR protein that is characterized by its extracellular domain, which consists of a catalytic active center and a conserved intracellular region.

The catalytic active center (CAC) of ADGRE5 is a unique feature that is found only in GPCR proteins. It is a heptahelical region that contains a Rossmann-fold, which is a structural motif that is commonly found in protein-ligand interactions. The Rossmann -fold is responsible for the catalytic activity of the CAC, which is involved in the regulation of various cellular processes, including cell adhesion.

ADGRE5 function

ADGRE5 is involved in the regulation of cell adhesion, which is a critical process that is involved in the development and maintenance of tissues and organs. Cell adhesion refers to the interaction between cells and the formation of tight junctions and adherens junctions, which are essential for the proper functioning of tissues.

One of the well-studied functions of ADGRE5 is its role in cell adhesion. ADGRE5 is involved in the regulation of the formation of tight junctions, which are a type of cell-cell adhesion structure that is formed by the interaction of cadherins and immunoglobulin- like cell adhesion molecules (IACs). tight junctions are critical for the proper functioning of various tissues, including the skin, heart, and lungs.

In addition to its role in cell adhesion, ADGRE5 is also involved in the regulation of other cellular processes. For example, it is involved in the regulation of cell proliferation, differentiation, and survival. In addition, ADGRE5 is involved in the regulation of cellular signaling, specifically in the regulation of angiogenesis and vascular remodeling.

Drug targeting ADGRE5

ADGRE5 is an attractive drug target due to its involvement in various cellular processes that are important for human health. As a result, several compounds have been developed that are designed to interact with ADGRE5 and modulate its function. These compounds have been tested in a variety of cellular and animal models and have shown to have a range of effects, including the regulation of cell adhesion, the regulation of cell proliferation, and the regulation of cellular signaling.

One of the most promising compounds that is currently being targeted by researchers is a small molecule called P1-16, which is a potent inhibitor of ADGRE5. P1-16 is currently being tested in a variety of cellular models to determine its efficacy as a drug for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Other compounds that have been shown to interact with ADGRE5 include small molecules, such as N-acylhydroxyamides (N-OHAs), which are found in various tissues and cells in the body. N-OHAs have been shown to be effective in modulating the

Protein Name: Adhesion G Protein-coupled Receptor E5

Functions: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration

The "ADGRE5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADGRE5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets