ADCY10: A Potential Drug Target and Biomarker for Cardiovascular Disease

Target Name: ADCY10

NCBI ID: G55811

ADCY10

ADCY10: A Potential Drug Target and Biomarker for Cardiovascular Disease

Cardiovascular disease is a leading cause of morbidity and mortality worldwide, placing a significant burden on public health and economic systems. The underlying causes of cardiovascular disease are complex, and several factors contribute to its development, including genetic, hormonal, and metabolic abnormalities. One of the key players in the regulation of cardiovascular function is the adenylate cyclase (AC), a protein that plays a crucial role in the production of nitric oxide, a potent vasodilator that relaxes blood vessels and improves blood flow. The adenylate cyclase gene (ACG) has four isoforms, ACG1, ACG2, ACG3, and ACG4, which differ in their expression and function. This gene is of interest as a potential drug target and biomarker for cardiovascular disease due to its involvement in the regulation of cardiovascular function and its potential impact on disease pathology.

Understanding ACG1 and ACG2

ACG1 and ACG2 are two of the four isoforms of the adenylate cyclase gene (ACG). Both isoforms are involved in the production of nitric oxide, but they differ in their expression and function. ACG1 is the most abundant isoform, and it is predominantly expressed in the heart, kidneys, and pancreas. It is also the only isoform that is known to function in the regulation of nitric oxide production. On the other hand, ACG2 is expressed in the liver, and it is involved in the regulation of fatty acid oxidation, which is not directly related to nitric oxide production.

The function of ACG1 is crucial for the regulation of nitric oxide production, as it is the only isoform that is involved in the production of nitric oxide in the body. Nitric oxide is a potent vasodilator and has been shown to have a wide range of cardiovascular benefits, including the relaxation of blood vessels, improved blood flow, and decreased inflammation. The production of nitric oxide by ACG1 is regulated by several factors, including angiotensin II, a hormone that is secreted by the adrenal gland in response to increased blood pressure, and nitric oxide synthase (NOS), a enzyme that is involved in the production of nitric oxide from other molecules.

ACG2 is also involved in the regulation of nitric oxide production, but its function is not as well understood. Some studies have suggested that ACG2 may be involved in the regulation of fatty acid oxidation, which is not directly related to nitric oxide production. However, further research is needed to fully understand the function of ACG2 in the regulation of nitric oxide production.

The Potential Role of ADCY10 in Cardiovascular Disease

The adenylate cyclase gene (ACG) has been implicated in the regulation of cardiovascular function, and its potential role in the development and progression of cardiovascular disease has received significant attention. Several studies have suggested that changes in the expression and function of ACG1 and ACG2 may contribute to the development of cardiovascular disease.

First, changes in the expression and function of ACG1 have been implicated in the development of cardiovascular disease. Several studies have shown that individuals with decreased ACG1 expression or function are at increased risk of developing cardiovascular disease, including heart failure, hypertension, and angina. Additionally, individuals with mutations in the ACG gene have been shown to have an increased risk of developing cardiovascular disease.

Second, changes in the function of ACG2 have also been implicated in the development of cardiovascular disease. Several studies have shown that individuals with decreased ACG2 function are at increased risk of developing cardiovascular disease, including heart failure and hypertension. Additionally, individuals with mutations in the ACG2 gene have been shown to have an increased risk of developing cardiovascular disease.

The potential role of ADCY10 in cardiovascular disease is further supported by its expression and function in the regulation of nitric oxide production. As mentioned earlier, ACG1 is the only isoform of the ACG gene that is involved in the production of nitric oxide in the body, and its function in this regard is crucial for the regulation of cardiovascular function. Therefore, changes in the expression and function of ACG1

Protein Name: Adenylate Cyclase 10

Functions: Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988)

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•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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