ADCY5: Key Enzyme in Adenosine Cycle and Potential Drug Target

Target Name: ADCY5

NCBI ID: G111

ADCY5

ADCY5: Key Enzyme in Adenosine Cycle and Potential Drug Target

ADCY5, or adenylyl cyclase 5, is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the cycle of adenosine, which is a molecule that plays a crucial role in many cellular processes. In this article, we will discuss ADCY5 as a drug target and its potential as a biomarker for various diseases.

ADCY5 is a member of the cyclase family, which includes enzymes that regulate the cycle of various molecules, including adenosine. Adenosine is a highly potent molecule that has a wide range of physiological effects throughout the body. It plays a critical role in the regulation of inflammation, stress responses, and sleep-wake cycles.

One of the key functions of ADCY5 is its role in the regulation of adenosine levels in the body. ADCY5 is responsible for breaking down adenosine, which is a byproduct of cellular metabolism. By breaking down adenosine, ADCY5 helps to maintain the levels of this molecule in the body, which is important for maintaining proper physiological function.

ADCY5 is also involved in the regulation of inflammation. When the body is exposed to an infection or injury, ADCY5 is activated and helps to facilitate the immune response. By activating immune cells and regulating the production of pro-inflammatory molecules, ADCY5 helps to prevent excessive inflammation that could cause tissue damage.

In addition to its role in inflammation, ADCY5 is also involved in the regulation of stress responses. When the body is exposed to stress, ADCY5 is activated and helps to regulate the production of stress hormones. This helps to maintain the body's stress response at a level that is appropriate for the situation.

ADCY5 is also involved in the regulation of sleep-wake cycles. It is responsible for breaking down the molecule melatonin, which is produced by the pineal gland in order to regulate the body's sleep-wake cycle. Melatonin is a hormone that helps to regulate the body's internal clock, and it is important for maintaining proper sleep-wake cycles.

As a drug target, ADCY5 has the potential to be a treatment for a wide range of conditions. For example, it is being studied as a potential treatment for insomnia, which is a common sleep disorder that affects millions of people around the world. Insomnia has been associated with a number of potential health risks, including increased risk of depression, anxiety, and cardiovascular disease.

In addition to its potential as an insomnia treatment, ADCY5 may also be a useful biomarker for the diagnosis of other sleep disorders. For example, some studies have suggested that ADCY5 may be involved in the regulation of the sleep-wake cycle in individuals with narcolepsy, which is a sleep disorder that is characterized by insomnia, hypersomnia, and other symptoms.

In addition to its potential as a treatment and biomarker, ADCY5 is also of interest to researchers as a potential target for drug discovery. By studying the role of ADCY5 in various physiological processes, researchers may be able to identify new drugs that can modulate its activity. This could lead to the development of new treatments for a wide range of conditions.

Overall, ADCY5 is a protein that is expressed in various tissues throughout the body that plays a critical role in the regulation of adenosine and its various physiological effects. As a drug target and biomarker, ADCY5 has the potential to be a valuable tool for the development of new treatments for a wide range of conditions.

Protein Name: Adenylate Cyclase 5

Functions: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569)

The "ADCY5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADCY5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets