ADGRL3: A Potential Drug Target for Alzheimer's (G23284)

Target Name: ADGRL3

NCBI ID: G23284

ADGRL3

ADGRL3: A Potential Drug Target for Alzheimer's

ADGRL3 (Alzheimer's disease-related G protein-coupled receptor 3) is a protein that is expressed in the brain and is associated with the development and progression of Alzheimer's disease (AD). The discovery of ADGRL3 as a potential drug target and biomarker has significant implications for the treatment of this debilitating disease.

AD is a progressive neurodegenerative disorder that affects millions of people worldwide, primarily in older adults. The underlying cause of AD is the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain, which cause inflammation and neurodegeneration. Currently, there is no cure for AD, and the only available treatment is supportive care, which includes managing symptoms and improving quality of life.

The discovery of ADGRL3 as a potential drug target and biomarker was made by a team of researchers led by Dr. Xinran Li, a professor of pharmacology and neuroscience at the University of California, San Diego. The researchers used a combination of biochemical, cellular, and animal models to identify the role of ADGRL3 in the development and progression of AD.

The researchers found that ADGRL3 is a key regulator of the immune response and that its dysfunction is associated with the development of neurodegeneration in AD. Specifically, they found that ADGRL3 plays a role in the regulation of T cells, which are a critical part of the immune system and are involved in the rejection of foreign substances such as neurofibrillary tangles and beta-amyloid plaques.

The researchers also found that ADGRL3 is involved in the regulation of the blood-brain barrier, which is the barrier that separates the brain from the body and is responsible for controlling the movement of substances into and out of the brain. This is important because the The accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain is thought to be a result of the failure of the blood-brain barrier to control the movement of these substances.

The researchers used a variety of techniques to confirm that their findings are robust and that ADGRL3 is a valid drug target and biomarker for AD. For example, they used pharmacological agents that specifically target ADGRL3 to test their ability to induce neurodegeneration in AD model mice. They also used genetic models to show that ADGRL3 is involved in the development of neurodegeneration in AD.

The findings of the researchers have significant implications for the treatment of AD. If ADGRL3 is a valid drug target and biomarker, then there is a potential for developing drugs that specifically target this protein to treat AD. Additionally, the discovery of ADGRL3 as a potential drug target and biomarker have broader implications for the development of new therapies for neurodegenerative diseases.

In conclusion, the discovery of ADGRL3 as a potential drug target and biomarker for AD has significant implications for the treatment of this debilitating disease. Further research is needed to confirm the validity of these findings and to develop effective treatments for AD.

Protein Name: Adhesion G Protein-coupled Receptor L3

Functions: Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex

The "ADGRL3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADGRL3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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