ADCY7: A Potential Drug Target for CAMP Regulation (G113)

Target Name: ADCY7

NCBI ID: G113

ADCY7

ADCY7: A Potential Drug Target for CAMP Regulation

ADCY7, also known as Adenylate Cyclase 7, is a protein that is expressed in various tissues throughout the body. It is involved in the catalytic cycle of adenylate cyclase, which is a key enzyme in the production of cyclic AMP (cAMP), a crucial signaling molecule that plays a vital role in various physiological processes. The transcript variant 1 of ADCY7 has been identified and is considered to be a potential drug target or biomarker.

The ADCY7 protein is composed of 214 amino acid residues and has a calculated molecular mass of 23.9 kDa. It is expressed in various tissues, including the heart, skeletal muscles, liver, and kidneys. It is highly expressed in the heart and is also found in the brain, where it is involved in the regulation of neuronal excitability. ADCY7 is also expressed in the lungs, where it is involved in the regulation of gas exchange.

One of the unique features of ADCY7 is its role in the regulation of cAMP production. ADCY7 is the catalytic subunit of the cyclic AMP-protein-catalytic subunit (CAP) complex, which is responsible for the production of cAMP from the amino acids acetyl-CoA and inositol. The CAP complex is a key enzyme in the production of cAMP, which is a crucial signaling molecule that plays a vital role in various physiological processes, including muscle contractions, blood pressure, and inflammation.

The role of ADCY7 in the regulation of cAMP production is important for understanding the mechanisms underlying various physiological processes. For example, the activity of ADCY7 has been shown to be regulated by various factors, including the levels of calcium ions and the levels of inhibitors that can inhibit its catalytic activity.

In addition to its role in the regulation of cAMP production, ADCY7 is also involved in the regulation of various cellular processes. For example, it is involved in the production of various signaling molecules, including nitric oxide, which is involved in cardiovascular function, and in the regulation of protein synthesis and degradation.

The transcript variant 1 of ADCY7 has been identified and is considered to be a potential drug target or biomarker. The production of cAMP by ADCY7 can be inhibited by various compounds, including dihydroorotate (DHOD), a inhibitor of the cyclic AMP-protein-catalytic subunit (CAP) complex. The inhibition of ADCY7 by DHOD has been shown to have a beneficial effect on various physiological processes, including the regulation of muscle contractions and the regulation of blood pressure.

In conclusion, ADCY7 is a protein that is involved in the regulation of various physiological processes. The transcript variant 1 of ADCY7 has been identified and is considered to be a potential drug target or biomarker. The inhibition of ADCY7 by DHOD has been shown to have a beneficial effect on various physiological processes, including the regulation of muscle contractions and the regulation of blood pressure. Further research is needed to fully understand the role of ADCY7 in various physiological processes and to develop effective strategies for the treatment of diseases that are characterized by the disruption of these processes.

Protein Name: Adenylate Cyclase 7

Functions: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity)

The "ADCY7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADCY7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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