CIDEA: A Potential Drug Target and Biomarker for Cell Death Inducing DFFA-like Effector A

Target Name: CIDEA

NCBI ID: G1149

CIDEA

CIDEA: A Potential Drug Target and Biomarker for Cell Death Inducing DFFA-like Effector A

Cell death is a natural and essential process in the life of all living organisms. However, when cells die under unnecessary or excessive conditions, it can lead to various diseases, such as cancer, neurodegenerative diseases, and systemic inflammatory diseases. Therefore, the study of cell death and its regulation is of great interest and importance.

One of the underlying mechanisms of cell death is the production of reactive oxygen species (ROS), which can cause damage to cellular components and contribute to the development of various diseases. Recently, it has been found that reactive oxygen species can induce cell death by activating cell death-inducing factor A (DFFA) and activating its downstream effectors, such as caspases.

CIDEA: A Potential Drug Target

CIDEA (cell death-inducing DFFA-like effector A) is a protein that was first identified as a potential drug target for cancer. It is a 21-kDa protein that belongs to the DFFA-like family and is expressed in various tissues and organs, including brain, heart, and gastrointestinal tract.

CIDEA has been shown to promote cell death by activating DFFA and its downstream effectors. DFFA is a pro-inflammatory protein that can induce cell death by activating various downstream effectors, including caspases.

CIDEA has been shown to promote the production of ROS by activating various cellular pathways, such as the mitochondrial pathway and the endoplasmic reticulum pathway. ROS can cause damage to cellular components and contribute to the development of various diseases.

CIDEA has also been shown to promote the formation of reactive oxygen species (ROS) by activating various cellular pathways, such as the glucose pathway and the fatty acid oxidation pathway. ROS can cause damage to cellular components and contribute to the development of various diseases.

CIDEA has been shown to promote the translation of its pre-mRNA into the protein pool by activating various cellular pathways, such as the signal transduction pathway and the apoptosis-associated protein (AP-1) pathway. This can lead to the production of CIDEA protein and contribute to its role in cell death.

CIDEA as a Potential Biomarker

CIDEA has been shown to be involved in various cellular processes, including cell death, inflammation, and signaling pathways. Therefore, it has potential as a biomarker for various diseases.

CIDEA has been shown to be involved in cancer development. For example, it has been shown to promote the growth and metastasis of various cancer cell lines, including breast, ovarian, and colorectal cancer.

CIDEA has also been shown to be involved in neurodegenerative diseases. For example, it has been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

CIDEA has also been shown to be involved in inflammatory diseases. For example, it has been shown to contribute to the development of inflammatory diseases, such as rheumatoid arthritis and Crohn's disease.

Conclusion

CIDEA is a protein that has been shown to promote cell death by activating DFFA and its downstream effectors. It is expressed in various tissues and organs and is potential drug target and biomarker for various diseases. Further studies are needed to fully understand the role of CIDEA in cell death and its potential as a drug target and biomarker.

Protein Name: Cell Death Inducing DFFA Like Effector A

Functions: Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity)

The "CIDEA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CIDEA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets