PASD1: A Promising Drug Target and Biomarker for Parkinson's Disease

Target Name: PASD1

NCBI ID: G139135

PASD1

PASD1: A Promising Drug Target and Biomarker for Parkinson's Disease

Introduction

Parkinson's disease is a common degenerative disease of the nervous system, which is mainly characterized by the gradual loss of the patient's motor ability, eventually leading to limited motor function. The pathogenesis of Parkinson's disease is not yet fully understood, but studies have found that Parkinson's disease may be closely related to the damage and death of dopaminergic neurons within neurons. Therefore, therapeutic targets for Parkinson's disease mainly focus on dopaminergic neurons in the central nervous system.

PASD1: a potential drug target

PASD1 is a transcription factor whose gene is located in the brain tissue of Parkinson's disease patients. Studies have found that PASD1 is upregulated in the brain tissue of patients with Parkinson's disease and is significantly related to the severity and motor symptoms of Parkinson's disease. In addition, PASD1 is also closely related to the damage and death of intraneuronal dopaminergic neurons.

The role and mechanism of PASD1 in Parkinson's disease

The role of PASD1 in Parkinson's disease is mainly reflected in the following aspects:

1. Regulation of PASD1 gene expression

Studies have found that the expression of PASD1 gene is up-regulated in the brain tissue of patients with Parkinson's disease, which is an important basis for the role of PASD1 in Parkinson's disease. The expression of PASD1 gene can be regulated in various ways, including post-transcriptional regulation, RNA-binding protein regulation, etc. These regulatory mechanisms allow the PASD1 gene to be stably expressed in Parkinson's disease.

2. PASD1 and dopaminergic neuron damage and death

In the brain tissue of patients with Parkinson's disease, dopaminergic neurons are damaged and die, resulting in a reduction in the number of dopaminergic neurons in the striatum, leading to the symptoms of Parkinson's disease. Studies have found that PASD1 plays an important role in the damage and death of dopaminergic neurons. PASD1 can regulate the growth, differentiation and apoptosis of dopaminergic neurons in various ways, thereby affecting the symptoms of Parkinson's disease.

3. The relationship between PASD1 and Parkinson鈥檚 disease symptoms

Studies have found that elevated PASD1 gene expression levels are an important predictor of Parkinson's disease symptom severity and movement disorders. Further research found that the reduction in PASD1 gene expression levels is an important reason for the limitation of motor function in patients with Parkinson's disease. These findings provide new targets for Parkinson's disease treatment.

Clinical application prospects of PASD1

As a potential drug target, PASD1 has broad application prospects in the treatment of Parkinson's disease. Currently, multiple research teams are exploring the application of PASD1 in the treatment of Parkinson's disease. For example, some research teams are exploring the use of PASD1 inhibitors to treat Parkinson's disease to improve patients' symptoms and quality of life.

Conclusion

Parkinson's disease is a common neurodegenerative disease whose pathogenesis is not fully understood. However, research has found that Parkinson's disease may be closely related to the damage and death of dopaminergic neurons within neurons. PASD1 is a potential drug target with broad prospects for application in the treatment of Parkinson's disease. Future research should further explore the mechanism of PASD1 in Parkinson's disease and provide new ideas and methods for the treatment of Parkinson's disease.

Protein Name: PAS Domain Containing Repressor 1

Functions: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801)

The "PASD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PASD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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