Discovery and Characterization of PPP4R3C as A Potential Drug Target

Target Name: PPP4R3C

NCBI ID: G139420

PPP4R3C

Discovery and Characterization of PPP4R3C as A Potential Drug Target

PPP4R3C (P4R3C_HUMAN) is a protein that is expressed in various tissues of the human body. It is a key regulator of the poly(ADP-ribose) polymerase (PARP) gene, which is involved in the repair of DNA damage. PARP is a crucial enzyme in the cell response to DNA damage, and it is often targeted by drugs that are designed to inhibit its activity.

The discovery and characterization of PPP4R3C as a potential drug target is an exciting development in the field of pharmacology. PPP4R3C has been shown to play a critical role in the regulation of cellular processes that are important for the development and maintenance of cancer. In addition, its dysfunction has been implicated in a variety of diseases, including neurodegenerative disorders, cardiomyopathy, and cancer.

Expression and Localization

PPP4R3C is a 21-kDa protein that is expressed in various tissues of the human body, including muscle, liver, kidney, and brain. It is predominantly expressed in the nuclei of the cells and is also found in the cytoplasm. PPP4R3C has been shown to localize to the nuclear envelope, where it can interact with various nuclear proteins, including histone modifications and non-histone modifications.

Function and Regulation

PPP4R3C is a key regulator of the poly(ADP-ribose) polymerase (PARP) gene, which is involved in the repair of DNA damage. PARP is a crucial enzyme in the cell response to DNA damage, and it is often targeted by drugs that are designed to inhibit its activity.

PPP4R3C functions as a negative regulator of PARP, by binding to its active site and inhibiting its catalytic activity. This interaction between PPP4R3C and PARP is critical for the regulation of DNA repair processes. PPP4R3C has been shown to play a critical role in the regulation of cellular processes that are important for the development and maintenance of cancer.

In addition, PPP4R3C has also been shown to play a role in the regulation of cellular processes that are important for the survival and reproduction of living organisms. For example, PPP4R3C has been shown to be involved in the regulation of cell cycle progression, apoptosis, and autophagy.

Dysfunction and Disease

The dysfunction of PPP4R3C has been implicated in a variety of diseases, including neurodegenerative disorders, cardiomyopathy, and cancer.

For example, PPP4R3C dysfunction has been shown to be involved in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In these conditions, the dysfunction of PPP4R3C has been shown to contribute to the progression of neurodegeneration and the development of neurofibrillary tangles.

PPP4R3C dysfunction has also been implicated in the development and progression of cardiomyopathy, a condition in which the heart muscle becomes weakened and less efficient in pumping blood. In these conditions, PPP4R3C dysfunction has been shown to contribute to the development of cardiomyopathy and the progression of the disease.

In addition, PPP4R3C dysfunction has also been implicated in the development and progression of a variety of cancers, including breast, lung, and ovarian cancers. In these conditions, PPP4R3C dysfunction has been shown to contribute to the regulation of cellular processes that are important for cancer growth and survival.

Molecular Mechanisms

The molecular mechanisms underlying the function of PPP4R3C are not well understood. However, several studies have shown that PPP4R3C functions as a negative regulator of PARP, by binding to its active site and inhibiting its catalytic activity.

PPP4R3C has been shown to interact with several other nuclear proteins, including histone modifications and non-histone modifications. For example, PPP4R3C has been shown to interact with

Protein Name: Protein Phosphatase 4 Regulatory Subunit 3C

The "PPP4R3C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP4R3C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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