RDH12: Enzyme for Healthy Skins (G145226)

Target Name: RDH12

NCBI ID: G145226

RDH12

RDH12: Enzyme for Healthy Skins

RDH12 (retinol dehydrogenase 12) is an enzyme involved in the metabolism of retinol, a crucial nutrient for the skin and hair. Retinol is a derivative of vitamin A, which plays a vital role in various cellular processes, including cell growth, differentiation, and barrier formation. However, too much retinol can cause negative effects, such as skin irritation and increased sun sensitivity. The enzyme RDH12 helps regulate the amount of retinol produced, thereby ensuring the safe use of this beneficial nutrient.

The all-trans and 9-cis forms of RDH12

RDH12 is an enzyme that catalyzes the conversion of all-trans retinol to 9-cis retinol. All-trans retinol is a metabolite that is found in high concentrations in the skin and hair. On the other hand, 9-cis retinol is a more potent metabolite that is responsible for the majority of the benefits associated with retinol.

The all-trans and 9-cis forms of RDH12 are derived from a single gene by alternative splicing. All-trans retinol is generated by the addition of a C-terminal acetyl group to the 尾-carboxylic acid residue of the enzyme. This modification allows all-trans retinol to interact with various cellular components, including transcription factors and signaling pathways.

9-cis retinol, on the other hand, is generated by the removal of the C-terminal acetyl group. This metabolite is more potent than all-trans retinol, as it has better water solubility and is more easily absorbed into the skin. It also has a more neutral pH, which is essential for its stability and bioavailability.

The role of RDH12 in skin health

RDH12 plays a crucial role in maintaining healthy skin. The all-trans and 9-cis forms of RDH12 have been shown to promote skin cell growth, differentiation, and barrier formation. They also regulate the production of sebum, which is essential for maintaining the skin's barrier function.

In addition, the all-trans and 9-cis forms of RDH12 have been linked to various skin conditions, including acne, rosacea, and skin aging. For instance, individuals with acne may have decreased levels of all-trans retinol in their skin, which could contribute to the condition. On the other hand, individuals with rosacea may have increased production of all-trans retinol, leading to redness and inflammation.

The potential benefits of targeting RDH12

Targeting RDH12 as a drug target or biomarker has significant potential in the development of treatments for various skin conditions. By inhibiting the activity of RDH12, researchers can reduce the production of all-trans retinol and increase the levels of 9-cis retinol, potentially improving skin health.

One approach to targeting RDH12 is through the development of small molecules that inhibit the activity of the enzyme. These molecules have been shown to be effective in treating a variety of skin conditions, including acne, rosacea, and skin aging. For instance, a class of drugs called retinol inhibitors has been shown to be effective in reducing the appearance of acne by targeting the production of all-trans retinol.

Another approach to targeting RDH12 is through the development of genetic tools that modify the expression of the enzyme. This approach has been used to study the role of RDH12 in various skin conditions. Researchers have used CRISPR/Cas9 technology to modify the expression of RDH12 in skin cells and have shown that these modifications can affect the skin's barrier function and cell growth.

Conclusion

In conclusion, RDH12 is an enzyme involved in the metabolism of retinol, which is a crucial nutrient for the skin and hair. The all-trans and 9-cis forms of RDH12 have been shown to promote skin cell growth, differentiation, and barrier formation, as well as regulate the production of sebum. Targeting RDH12 as a drug target or biomarker has significant potential in the development of treatments for various skin conditions. Further research is needed to fully understand the role of RDH12 in skin health and to develop effective treatments.

Protein Name: Retinol Dehydrogenase 12

Functions: Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:15865448, PubMed:12226107). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:19686838, PubMed:15865448). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:15865448, PubMed:12226107)

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