sFRP1: A Potential Drug Target and Biomarker (G6422)

Target Name: SFRP1

NCBI ID: G6422

SFRP1

sFRP1: A Potential Drug Target and Biomarker

Sfrp1, short for solute carrier family 1 member 1, is a protein that plays a critical role in the function of endothelial cells. Endothelial cells line the blood vessels and are responsible for maintaining blood pressure. Sfrp1 helps regulate the movement of molecules into and out of endothelial cells, which is essential for maintaining the integrity of blood vessels.

Sfrp1 is a transmembrane protein that is expressed in a variety of tissues, including the brain, heart, and blood vessels. It is a protein that is composed of four subunits, which are responsible for its unique structure and function.

One of the unique features of sfrp1 is its ability to interact with other proteins that are expressed in the endothelial cell membrane. This interaction between sfrp1 and its partners is critical for the regulation of endothelial cell function.

Sfrp1 has also been shown to play a role in the development and progression of certain diseases. For example, studies have shown that sfrp1 is expressed in the endothelial cells that line the blood vessels in patients with heart failure. Additionally, sfrp1 has been shown to be involved in the development of cancer, and may be a potential biomarker for this disease.

Due to its involvement in the regulation of endothelial cell function and its potential role in the development of certain diseases, sfrp1 has caught the attention of researchers as a potential drug target. Researchers are currently working to develop small molecules that can inhibit sfrp1's activity and use it as a treatment for a variety of conditions, including heart failure, cancer, and other diseases.

In addition to its potential as a drug target, sfrp1 is also a potential biomarker. The regulation of endothelial cell function by sfrp1 is a critical aspect of the development and maintenance of blood vessels, and changes in this regulation have been associated with the development of certain diseases. Therefore, measuring sfrp1's expression and activity may be a useful diagnostic tool for these diseases.

Overall, sfrp1 is a protein that has the potential to be a drug target and biomarker. Further research is needed to fully understand its role in the regulation of endothelial cell function and its potential as a treatment for various diseases.

Protein Name: Secreted Frizzled Related Protein 1

Functions: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription

The "SFRP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SFRP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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