ZNF480: A Key Regulator of Neural Development and Plasticity (G147657)
ZNF480: A Key Regulator of Neural Development and Plasticity
ZNF480 (ZN480_HUMAN), a protein encoded by the ZNF4 gene, is a key regulator of neural development, neurotransmission, and survival. The ZNF4 gene is located on chromosome 6 (6p) and has four splice variants, ZNF46, ZNF47, ZNF48, and ZNF49. ZNF480 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and peripheral tissues.
The ZNF4 gene is responsible for the production of a family of proteins that are involved in the regulation of neural development, including ZNF2, ZNF3, ZNF5, ZNF6, ZNF7, ZNF9, and ZNF10. These proteins play a crucial role in the development and maintenance of neural stem cells, which are the foundation of the nervous system.
ZNF480 is a key regulator of neural stem cell proliferation and differentiation. It is able to induce the stem cells to differentiate into functional neurons that are capable of transmitting electrical signals. ZNF480 has been shown to play a role in the regulation of neuronal excitability and synaptic plasticity, which are critical for the function of neural stem cells.
In addition to its role in neural stem cell biology, ZNF480 is also involved in the regulation of stem cell plasticity and in the development of cancer. It has been shown to be involved in the regulation of cell cycle progression, apoptosis, and autophagy.
Given its involvement in neural development and plasticity, ZNF480 is a potential drug target for the treatment of a variety of neurological and psychiatric disorders. For example, ZNF480 has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
In addition to its potential therapeutic applications, ZNF480 is also a valuable biomarker for the diagnosis and monitoring of these disorders. The ZNF480 protein has been shown to be decreased in the brains of individuals with neurodegenerative diseases, which suggests that it may be a useful diagnostic or monitoring protein.
In conclusion, ZNF480 is a protein that is involved in the regulation of neural development and plasticity. It is a potential drug target for the treatment of neurological and psychiatric disorders and can also be used as a biomarker for the diagnosis and monitoring of these disorders. Further research is needed to fully understand the role of ZNF480 in neural development and plasticity, as well as its potential therapeutic and diagnostic applications.
Protein Name: Zinc Finger Protein 480
Functions: Involved in transcriptional regulation as an activator
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• expression level;
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More Common Targets
ZNF483 | ZNF484 | ZNF485 | ZNF486 | ZNF487 | ZNF488 | ZNF490 | ZNF491 | ZNF492 | ZNF493 | ZNF496 | ZNF497 | ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507 | ZNF510 | ZNF511 | ZNF512 | ZNF512B | ZNF513 | ZNF514 | ZNF516 | ZNF516-DT | ZNF517 | ZNF518A | ZNF518B | ZNF519 | ZNF519P3 | ZNF521 | ZNF524 | ZNF525 | ZNF526 | ZNF527 | ZNF528 | ZNF528-AS1 | ZNF529 | ZNF529-AS1 | ZNF530 | ZNF532 | ZNF534 | ZNF536 | ZNF540 | ZNF541 | ZNF542P | ZNF543 | ZNF544 | ZNF546 | ZNF547 | ZNF548 | ZNF549 | ZNF550 | ZNF551 | ZNF552 | ZNF554 | ZNF555 | ZNF556 | ZNF557 | ZNF558 | ZNF559 | ZNF559-ZNF177 | ZNF560 | ZNF561 | ZNF561-AS1 | ZNF562 | ZNF563 | ZNF564 | ZNF565 | ZNF566 | ZNF566-AS1 | ZNF567 | ZNF568 | ZNF569 | ZNF56P | ZNF57 | ZNF570 | ZNF571 | ZNF571-AS1 | ZNF572 | ZNF573 | ZNF574 | ZNF575 | ZNF576 | ZNF577 | ZNF578 | ZNF579 | ZNF580 | ZNF582 | ZNF582-DT | ZNF583 | ZNF584 | ZNF585A | ZNF585B | ZNF586 | ZNF587
