HSCB: A Key Regulator of DNA Double Helix in Eukaryotic Cells

Target Name: HSCB

NCBI ID: G150274

HSCB

HSCB: A Key Regulator of DNA Double Helix in Eukaryotic Cells

The HSCB (DnaJ (Hsp40) homolog, subfamily C, member 20) protein is a key regulator of the DNA double helix in eukaryotic cells. It is a member of the HSP40 protein family, which are known for their ability to interact with DNA in a variety of organisms, including bacteria, archaea, and eukaryotes. HSP40 proteins play a crucial role in ensuring the stability and integrity of DNA, as well as the regulation of various cellular processes.

HSCB is a 20kDa protein that is expressed in various tissues and cells throughout the body. It is highly conserved, with a calculated amino acid sequence of 211 amino acids. HSCB is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the cytoplasm . It has been shown to interact with various DNA-binding proteins, including the DNA-binding domain of the protein component DNAJ.

HSCB functions as a critical regulator of the DNA double helix. It plays a crucial role in the regulation of DNA replication, repair, and post-transcriptional modification. HSCB is involved in the regulation of DNA-bound proteins, including histone modifications, which are important for the regulation of gene expression and chromatin structure.

HSCB is also involved in the regulation of various cellular processes, including cell adhesion, migration, and the regulation of cell cycle progression. It has been shown to interact with various cell adhesion molecules, including cadherins and integrins, and is involved in the regulation of cell-cell adhesion.

HSCB is also involved in the regulation of DNA damage repair. It has been shown to interact with the protein group component DNAJ, which is also involved in DNA damage repair. HSCB functions as a negative regulator of DNAJ, which ensures that the DNAJ protein is in aDNA-binding active state and that it can interact with DNA.

HSCB is also involved in the regulation of cellular signaling pathways. It has been shown to interact with various signaling proteins, including the protein kinaseA2 (PKA) and the protein tyrosine kinase (TK). HSCB functions as a negative regulator of PKA, which ensures that the PKA protein is in an active state and can interact with DNA.

In conclusion, HSCB is a key regulator of the DNA double helix in eukaryotic cells. It plays a crucial role in the regulation of DNA replication, repair, post-transcriptional modification, cell adhesion, migration, and the regulation of DNA damage repair and cellular signaling pathways. As a drug target, HSCB may be useful in targeting various cellular processes that are disrupted in diseases such as cancer, neurodegenerative diseases, and genetic disorders.

Protein Name: HscB Mitochondrial Iron-sulfur Cluster Cochaperone

Functions: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (PubMed:20668094). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Plays an essential role in hematopoiesis (By similarity)

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