Targeting ETF Subunit: A Potential Approach To Therapeutic Developments

Target Name: ETFBKMT

NCBI ID: G254013

ETFBKMT

Targeting ETF Subunit: A Potential Approach To Therapeutic Developments

Electron transfer flavoprotein (ETF)尾 subunit is a key protein in the electron transport chain of the cell's mitochondria. It plays a crucial role in the production of reactive oxygen species (ROS), which can damage cellular components and contribute to a variety of diseases, including neurodegenerative disorders, cancer, and aging. Moreover, ETF尾 subunit is also involved in the regulation of cellular signaling pathways, including apoptosis. Therefore, targeting ETF尾 subunit has the potential to lead to new therapeutic approaches for a variety of diseases.

Disease-related functions of ETF尾 subunit

ETF尾 subunit is involved in several disease-related functions, including:

1. Oxidative stress: ETF尾 subunit is a key protein in the electron transport chain that generates reactive oxygen species (ROS) during the production of ATP. These ROS can damage cellular components and contribute to the development of oxidative stress-related diseases, such as neurodegenerative disorders, cancer, and aging.

2. Cell signaling pathways: ETF尾 subunit is involved in the regulation of several cellular signaling pathways, including apoptosis, cell cycle progression, and DNA replication. These signaling pathways play crucial roles in the development and progression of many diseases, including cancer.

3. Metabolism: ETF尾 subunit is involved in the metabolism of several essential nutrients, including nitrogen, carbon, and oxygen. These nutrients are essential for the survival and growth of cells, and alterations in their metabolism can contribute to the development of diseases.

Targeting ETF尾 subunit as a drug or biomarker

Targeting ETF尾 subunit as a drug or biomarker has the potential to lead to new therapeutic approaches for a variety of diseases. Here are some potential strategies for targeting ETF尾 subunit:

1. Small molecule inhibitors: Small molecules can be used to inhibit the activity of ETF尾 subunit. These inhibitors can be designed to specifically target the protein, either by blocking its activity directly or by modulating its expression levels. One example of a small molecule inhibitor that targets ETF尾 subunit is 2-methylpropionitrile (2-MP), which is a potent inhibitor of the enzyme tryptophan hydroxylase ( TrypH), which is a key enzyme in the synthesis of tryptophan, a key amino acid involved in the synthesis of ETF尾 subunit.

2. Monoclonal antibodies: Monoclonal antibodies (MCAs) can be used to target ETF尾 subunit directly. These antibodies can be designed to recognize specific epitopes (validated by the manufacturer) on the protein, allowing for targeted delivery to the protein and potentially reducing the risk of off-target effects. One example of a MCA that targets ETF尾 subunit is RG639, which is designed to recognize the amino acid Asp112 on ETF尾 subunit.

3. Adjuvant therapy: Adjuvant therapy involves the use of drugs in combination with other therapies to improve outcomes in cancer patients. One potential approach to targeting ETF尾 subunit is through the use of chemotherapy drugs that can modulate its expression levels. For example, the chemotherapy drug doxorubicin has been shown to reduce the expression of ETF尾 subunit in cancer cells, potentially by inhibiting its synthesis or stability.

4.ETF尾 subunit-targeted therapies: Another approach to targeting ETF尾 subunit is through the development of therapies that specifically target the protein itself. For example, researchers have developed small molecules that can specifically bind to ETF尾 subunit and inhibit its activity, potentially leading to a new treatment option for

Protein Name: Electron Transfer Flavoprotein Subunit Beta Lysine Methyltransferase

Functions: Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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