ETV6: A Potential Drug Target and Biomarker (G2120)
ETV6: A Potential Drug Target and Biomarker
ETV6 (ETV6_HUMAN), a protein that is expressed in the endoplasmic reticulum (ER), is a potential drug target and biomarker for various diseases, including cancer. Its unique expression pattern and functions in cellular signaling pathways make it an attractive target for researchers to study.
ETV6 is a 64-kDa protein that is expressed in most tissues and cells. It is highly expressed in the ER, with the highest expression levels observed in the liver, muscle, and placenta. ETV6 is a member of the evolutionarily conserved T-T-X repeat domain family, which is commonly found in transmembrane proteins. This family is known for its ability to form homophilic interactions, which can enhance protein-protein interactions and contribute to protein stability.
One of the most significant functions of ETV6 is its role in the regulation of cellular signaling pathways. ETV6 has been shown to play a critical role in the regulation of the PI3K/Akt signaling pathway, which is a well-established target for many diseases, including cancer.
The PI3K/Akt signaling pathway is a critical pathway that regulates various cellular processes, including cell growth, differentiation, and survival. This pathway is known for its ability to promote signaling through the formation of phosphatidylinositol (PI) molecules, which can then interact with various protein targets to regulate cellular processes.
ETV6 has been shown to be a positive regulator of the PI3K/Akt pathway. Studies have shown that ETV6 can physically interact with the protein Pyknot, which is a key regulator of the PI3K/Akt pathway. This interaction between ETV6 and Pyknot allows for the regulation of various cellular processes, including cell growth, differentiation, and survival.
In addition to its role in the PI3K/Akt pathway, ETV6 has also been shown to play a critical role in the regulation of the Wnt signaling pathway. The Wnt signaling pathway is a well-established target for many diseases, including cancer.
The Wnt signaling pathway is a critical pathway that regulates various cellular processes, including cell growth, differentiation, and survival. This pathway is known for its ability to promote signaling through the formation of Wnt proteins, which can then interact with various protein targets to regulate cellular processes.
ETV6 has been shown to be a negative regulator of the Wnt signaling pathway. Studies have shown that ETV6 can physically interact with the protein Twist, which is a key regulator of the Wnt signaling pathway. This interaction between ETV6 and Twist allows for the regulation of various cellular processes, including cell growth, differentiation, and survival.
In conclusion, ETV6 is a protein that has been shown to play a critical role in the regulation of cellular signaling pathways. Its unique expression pattern and functions in the ER make it an attractive target for researchers to study. Further research is needed to fully understand the unique mechanisms of ETV6 and its potential as a drug target and biomarker for various diseases.
Protein Name: ETS Variant Transcription Factor 6
Functions: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation
The "ETV6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ETV6 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
ETV7 | Eukaryotic translation initiation factor 2-alpha kinase | Eukaryotic translation initiation factor 2B | Eukaryotic translation initiation factor 3 (eIF-3) complex | Eukaryotic Translation Initiation Factor 4A (eIF-4A) | Eukaryotic Translation Initiation Factor 4E Binding Protein | EVA1A | EVA1A-AS | EVA1B | EVA1C | EVC | EVC2 | EVI2A | EVI2B | EVI5 | EVI5L | EVL | EVPL | EVPLL | EVX1 | EVX1-AS | EVX2 | EWSAT1 | EWSR1 | EXD1 | EXD2 | EXD3 | EXO1 | EXO5 | EXOC1 | EXOC1L | EXOC2 | EXOC3 | EXOC3-AS1 | EXOC3L1 | EXOC3L2 | EXOC3L4 | EXOC4 | EXOC5 | EXOC5P1 | EXOC6 | EXOC6B | EXOC7 | EXOC8 | Exocyst complex | EXOG | EXOGP1 | Exon junction complex | EXOSC1 | EXOSC10 | EXOSC10-AS1 | EXOSC2 | EXOSC3 | EXOSC4 | EXOSC5 | EXOSC6 | EXOSC7 | EXOSC8 | EXOSC9 | Exosome Complex | EXPH5 | EXT1 | EXT2 | EXTL1 | EXTL2 | EXTL2P1 | EXTL3 | EXTL3-AS1 | EYA1 | EYA2 | EYA3 | EYA4 | EYS | EZH1 | EZH2 | EZHIP | EZR | F10 | F11 | F11-AS1 | F11R | F12 | F13A1 | F13B | F2 | F2R | F2RL1 | F2RL2 | F2RL3 | F3 | F5 | F7 | F8 | F8A1 | F8A2 | F8A3 | F9 | FA2H | FAAH | FAAH2
