DOK3: A Potential Drug Target and Biomarker (G79930)

Target Name: DOK3

NCBI ID: G79930

DOK3

DOK3: A Potential Drug Target and Biomarker

Docking proteins are a type of protein that plays a crucial role in the process of protein-protein interactions, which are essential for various biological processes, including cell signaling, protein folding, and disease development. One of the well-known docking proteins is DOK3 , which is a member of the DOK family of proteins. DOK3 has been shown to be a potential drug target and biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The DOK family of proteins consists of five isoforms, including DOK1, DOK2, DOK3, DOK4, and DOK5, which differ in their sizes and localization to various cellular compartments. DOK3 is the smallest and most abundant isoform in the DOK family. It is a 16-kDa protein that consists of 115 amino acid residues and has a calculated pI of 6.4. DOK3 is predominantly expressed in the cytoplasm and is involved in various cellular processes, including cell signaling, intracellular signaling, and tissue homeostasis.

One of the most significant functions of DOK3 is its role in intracellular signaling. DOK3 has been shown to play a role in the regulation of mitochondrial function, as well as the regulation of cellular signaling pathways that are involved in cell growth, differentiation, and survival . DOK3 has been shown to interact with various cellular signaling proteins, including TOR, FAK, and PI3K. These interactions play a crucial role in the regulation of cellular processes that are critical for the survival and growth of cells.

DOK3 has also been shown to be involved in the regulation of inflammation and immune responses. DOK3 has been shown to interact with various immune molecules, including NF-kappa-B and PD-L1. These interactions contribute to the regulation of immune responses and the regulation of inflammation. DOK3 has also been shown to play a role in the regulation of cellular apoptosis, which is a critical mechanism that regulates cell death and has been implicated in the development of various diseases, including cancer.

In addition to its role in intracellular signaling and immune regulation, DOK3 has also been shown to be involved in the regulation of cellular transport processes. DOK3 has been shown to play a role in the regulation of mitochondrial transport, as well as the regulation of vesicular transport in the endoplasmic reticulum. These processes are critical for the regulation of cellular processes that are involved in the production and delivery of various cellular organelles, including enzymes and signaling molecules.

DOK3 has also been shown to be involved in the regulation of cellular signaling pathways that are involved in cell growth and survival. DOK3 has also been shown to play a role in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cellular signaling pathways that are involved in cell growth, survival, and angiogenesis. DOK3 has also been shown to interact with the protein kinase A1 (PKA1), which is involved in the regulation of various cellular processes, including cell signaling, protein folding, and DNA replication.

In conclusion, DOK3 is a protein that has been shown to play a crucial role in various cellular processes, including intracellular signaling, inflammation, and immune regulation. Its functions as a potential drug target and biomarker make it an attractive target for researchers to investigate the mechanisms of its role in the development and treatment of various diseases. Further research is needed to fully understand the role of DOK3 in cellular processes and its potential as a drug target and biomarker.

Protein Name: Docking Protein 3

Functions: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

The "DOK3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DOK3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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