HIPK1: A Key Regulator of Cell Signaling Pathways (G204851)

Target Name: HIPK1

NCBI ID: G204851

HIPK1

HIPK1: A Key Regulator of Cell Signaling Pathways

HIPK1, also known as HIPK1 variant 1, is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the Chagas disease, a disease caused by the parasite The diseases caused affect the health of millions of people around the world.

The crystal structure of HIPK1 is composed of two subunits, each containing a core 伪-helix and a 尾-coil extending along both ends. The two subunits are held together by non-covalent interactions to form a dimer. In the dimer of HIPK1, each subunit contains a specific region called the core binding domain (CBD).

CBD is a key region of the HIPK1 dimer, located at the binding site of the two subunits. It is the most functionally rich region in the HIPK1 dimer and contains many highly conserved amino acid residues, including many hydrophilic amino acids, which play an important role in the structure and function of HIPK1.

The CBD region of HIPK1 is highly specific, making it an attractive drug target. Many studies have shown that the CBD region of HIPK1 is an important target for the treatment of many neurological and cardiovascular diseases.

First, the CBD region of HIPK1 can be used as a drug target to treat neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Parkinson's disease is a common neurodegenerative disease characterized by muscle stiffness and decreased movement. The CBD region of HIPK1 could be used to treat Parkinson's disease because it regulates neuronal survival and synaptic transmission. Many studies have shown that the CBD region of HIPK1 can treat Parkinson's disease by inhibiting neuronal death and synaptic loss.

Second, the CBD region of HIPK1 could be used to treat cardiovascular disease. Cardiovascular disease is a global health problem that causes many deaths. The CBD region of HIPK1 could be used to treat cardiovascular disease because it plays an important role in regulating the contraction and relaxation of cardiomyocytes. Many studies have shown that the CBD region of HIPK1 can be used to treat cardiovascular disease problems such as high blood pressure, reduced heart rate and cardiac contractility.

In addition, the CBD region of HIPK1 could be used to treat other neurological and cardiovascular diseases. For example, the CBD region of HIPK1 could be used to treat multiple sclerosis, an autoimmune disease that causes neuronal death and loss of neurological function.

The CBD region of HIPK1 has attracted widespread attention as a drug target. Many researchers are exploring the potential of the CBD region of HIPK1 in treating neurological and cardiovascular diseases. Future research will help to delve deeper into the CBD region of HIPK1 and develop more effective treatments.

Protein Name: Homeodomain Interacting Protein Kinase 1

Functions: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171)

The "HIPK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HIPK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets