GJD4: Key Player in The Formation of The Blood-Brain Barrier (G219770)

Target Name: GJD4

NCBI ID: G219770

GJD4

GJD4: Key Player in The Formation of The Blood-Brain Barrier

GJD4 (also known as connexin-40.1) is a protein that is expressed in the brain and is involved in the formation of blood-brain barrier (BBB). The BBB is a specialized barrier that separates the brain from the surrounding bloodstream and plays a crucial role in ensuring the safety and security of the brain. GJD4 is a key player in this process, as its absence or dysfunction has been implicated in a number of neurological and psychiatric disorders.

GJD4 is a member of the connexin family of proteins, which are known for their role in cell-cell and cell-extracellular matrix (ECM) interactions. In the context of the brain, connexins help to maintain the structural integrity of neurons and glial cells, as well as play a role in the formation of the BBB.

GJD4 is expressed in the brain and is involved in the formation of the BBB.

The BBB is a specialized barrier that separates the brain from the surrounding bloodstream. It is made up of a series of transmembrane proteins that are arranged in a specific order. The first step in the formation of the BBB is the formation of the permeable endothelial cell layer, which is composed of endothelial cells that are joined to the underlying brain tissue. From there, GJD4 helps to regulate the migration and fusion of endothelial cells, as well as the production of tight junctions, which are a type of transmembrane protein that help to maintain the integrity of the barrier.

GJD4 is also involved in the regulation of the cytoskeleton. It helps to maintain the integrity of microtubules, which are the protein structures that make up the cytoskeleton and help to regulate cell movement. This is important for the proper functioning of the brain, as changes in microtubule stability have been implicated in a number of neurological and psychiatric disorders.

In addition to its role in the BBB and cytoskeleton, GJD4 has also been implicated in a number of other processes that are important for brain function. For example, it has been shown to play a role in the regulation of neurotransmitter release from neurons, which is important for the proper functioning of the brain. It has also been shown to be involved in the regulation of pain perception, which is an important aspect of brain function that can be affected by a wide range of factors, including neurotransmitter dysfunction.

GJD4 is a potential drug target for a variety of neurological and psychiatric disorders. Its role in the formation of the BBB and its involvement in the regulation of cell-cell and cell-extracellular matrix interactions make it a promising target for the development of new therapies for a range of brain disorders. Additionally, its role in the regulation of neurotransmitter release and its involvement in the regulation of pain perception make it a potential target for the development of new therapies for pain management.

GJD4 is also a potential biomarker for a number of neurological and psychiatric disorders. Its absence or dysfunction has been implicated in a number of disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Additionally, changes in the levels of GJD4 have been observed in a number of neuropsychiatric disorders, including depression and anxiety. These findings suggest that GJD4 may be a valuable biomarker for a range of brain disorders.

In conclusion, GJD4 is a protein that is involved in the formation of the blood-brain barrier and the regulation of the cytoskeleton. Its role in these processes, as well as its involvement in the regulation of neurotransmitter release and the regulation of pain perception, make it a promising target for the development of new therapies for a

Protein Name: Gap Junction Protein Delta 4

Functions: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell

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