GLRB: A Protein Implicated in Multiple Diseases (G2743)

Target Name: GLRB

NCBI ID: G2743

GLRB

GLRB: A Protein Implicated in Multiple Diseases

GLRB (GLRB_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the GLR family of proteins, which are involved in various cellular processes, including cell signaling and signaling pathways. GLRB has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, GLRB has become a promising drug target and a focus of research in the scientific community.

GLRB is a 21-kDa protein that is expressed in the brain, heart, and kidneys. It is characterized by a N-terminal transmembrane domain, a catalytic C-terminus, and a C-terminal cytoplasmic domain. The N-terminal transmembrane domain is responsible for GLRB's ability to interact with various signaling molecules, including tyrosine, which is a well-known protein that is involved in cell signaling. The catalytic C-terminus is known as an active site, which is responsible for GLRB's catalytic activity. The C-terminal cytoplasmic domain is involved in GLRB's stability and localization in the cell.

GLRB has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, GLRB has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. GLRB has also been shown to be involved in the development and progression of cancer, including breast and ovarian cancer. In addition, GLRB has been shown to be involved in the development and progression of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis.

GLRB has also been shown to be involved in several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. The TGF-β pathway is involved in cell signaling and is known for its role in the development and progression of cancer. The PI3K/Akt pathway is involved in cell signaling and is known for its role in the regulation of cell growth, differentiation, and survival. The NF-kappa-B pathway is involved in cell signaling and is known for its role in the regulation of inflammation and immune responses.

GLRB has also been shown to be involved in the regulation of cellular processes, including cell adhesion, migration, and invasion. GLRB has been shown to play a role in the regulation of cell adhesion by interacting with the protein E-cadherin. GLRB has also been shown to play a role in the regulation of cell migration and invasion by interacting with the protein T-cell adhesion molecule (CD47).

In conclusion, GLRB is a protein that is expressed in various tissues of the human body and is involved in several cellular processes, including cell signaling and signaling pathways. GLRB has been shown to play a role in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, GLRB has become a promising drug target and a focus of research in the scientific community. Further research is needed to fully understand the role of GLRB in the development and progression of disease and to develop effective treatments.

Protein Name: Glycine Receptor Beta

Functions: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488)

The "GLRB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GLRB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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