GLOD5: A Potential Drug Target and Biomarker (G392465)

Target Name: GLOD5

NCBI ID: G392465

GLOD5

Other Name(s): Glyoxalase domain containing 5 | GLOD5_HUMAN | Glyoxalase domain-containing protein 5 | glyoxalase domain containing 5

GLOD5: A Potential Drug Target and Biomarker

GLOD5, also known as Glyoxalase domain containing 5, is a gene that encodes a protein located in the endoplasmic reticulum (ER) of the cell. ER is a network of organelles responsible for protein synthesis, quality control, and degradation, and it is a critical pathway for the majority of cellular processes. As such, GLOD5 has been linked to various cellular processes, including protein homeostasis, cell signaling, and stress response.

The GLOD5 protein has unique farnesylated cysteine 鈥嬧?媟esidues, which are highly reactive and can undergo oxidation reactions, resulting in the formation of toxic cyclic oxides. This reaction is an important metabolic pathway in organisms, but excessive accumulation can lead to cell damage and disease. Therefore, it is important to study the role of GLOD5 in cellular metabolism and disease.

GLOD5 has also been shown to play a role in cellular signaling pathways. In cells, GLOD5 can bind to a variety of proteins, including some important signal transduction molecules, such as FAK, NF-kappa-B, and MAPK. These signal transduction molecules are involved in regulating a variety of biological processes, including cell proliferation, apoptosis, migration, and tumor formation. By studying the role of GLOD5 in these signal transduction molecules, the complex metabolic and signaling processes within cells can be better understood.

In addition, GLOD5 is also closely related to apoptosis. Apoptosis is an important form of cell death in many types of cells and is critical for maintaining tissue and organ homeostasis, clearing damaged cells, and maintaining the function of the immune system. Research shows that GLOD5 plays an important regulatory role in apoptosis.

GLOD5 is also associated with various diseases, including diabetes, cancer, and neurodegenerative diseases. For example, GLOD5 positivity is associated with an increased risk of diabetes because GLOD5 is involved in regulating intracellular glucose metabolism and intracellular fat storage. In addition, GLOD5 is also associated with many cancer types, such as lung cancer, liver cancer, and breast cancer.

Therefore, studying the biological functions and mechanisms of action of GLOD5 is of great significance for the development of new drug targets and treatment strategies. By inhibiting the activity of GLOD5, the progression of harmful metabolic pathways in cells can be slowed down or prevented, thereby providing new ideas and methods for the treatment of various diseases.

Protein Name: Glyoxalase Domain Containing 5

The "GLOD5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GLOD5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets