Understanding GLRA3: Unraveling The G Protein-coupled Receptor Type 3

Target Name: GLRA3

NCBI ID: G8001

GLRA3

Understanding GLRA3: Unraveling The G Protein-coupled Receptor Type 3

GLRA3 (G protein-coupled receptor type 3) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the G protein-coupled receptor family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling.

GLRA3 is involved in a wide range of physiological processes in the body, including sensory perception, pain signaling, and hormone regulation. It is also involved in several diseases, including diabetes, obesity, and neurodegenerative disorders.

Despite its importance, GLRA3 is not well understood. little is known about the structure and function of GLRA3, and there are few research studies on its role in disease.

One of the main challenges in studying GLRA3 is its high degree of genetic and molecular diversity. GLRA3 has several different splice variants, which may result in differences in the structure and function of the protein.

The GLRA3 gene has four splice variants, GLRA3-1, GLRA3-2, GLRA3-3, and GLRA3-4. These variants differ in the exon numbers and the presence or absence of certain genetic variants.

GLRA3-1, GLRA3-2, and GLRA3-4 are all involved in the same protein, but GLRA3-3 is a unique variant that is not found in any of the other splice variants.

While more research is needed, the available data suggests that GLRA3 is a protein that plays an important role in the regulation of various physiological processes in the body. It is involved in the signaling pathways that regulate sensory perception, pain signaling, and hormone regulation. It is also involved in the development and progression of diseases, including diabetes, obesity, and neurodegenerative disorders.

GLRA3 may also be a potential drug target or biomarker. The high degree of genetic and molecular diversity in GLRA3 makes it an attractive target for researchers to study and develop new treatments for various diseases.

One of the main potential drug targets for GLRA3 is its role in pain signaling. GLRA3 is involved in the production of pain signals, and it is possible that blocking its activity could be an effective way to treat pain.

Another potential drug target for GLRA3 is its role in the regulation of appetite and metabolism. GLRA3 is involved in the production of hunger and satiety signals, and it is possible that blocking its activity could be an effective way to treat obesity and type 2 diabetes.

In conclusion, GLRA3 is a protein that is involved in a wide range of physiological processes in the body. While more research is needed, the available data suggests that GLRA3 is a protein that plays an important role in the regulation of various physiological processes in the body. It is also a potential drug target or biomarker, and further research is needed to fully understand its role in disease.

Protein Name: Glycine Receptor Alpha 3

Functions: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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