PHLPP2-ALZ1: A Protein Implicated in TGF-β Signaling and Cellular Processes

Target Name: PHLPP2

NCBI ID: G23035

PHLPP2

PHLPP2-ALZ1: A Protein Implicated in TGF-β Signaling and Cellular Processes

PHLPP2 (Protein-Protein Interaction Gene 2) is a gene that encodes a protein known as PHLPP2-ALZ1. PHLPP2-ALZ1 is a protein that is expressed in various tissues and cells of the body, including the brain, heart, and blood vessels. It is involved in the regulation of cell signaling pathways, and is thought to play a role in the development and progression of various diseases.

One of the key functions of PHLPP2-ALZ1 is its role in the regulation of the TGF-β pathway, a critical pathway involved in the development and maintenance of tissues and organs. TGF-β is a cytokine that is involved in the regulation of cell growth, differentiation, and inflammation.PHLPP2-ALZ1 has been shown to play a role in the regulation of TGF-β activity by interacting with several of its downstream targets, including the transcription factor PDGF-未 and the protein kinase PYR (Pyruvate Kinase).

In addition to its role in TGF-β signaling, PHLPP2-ALZ1 is also involved in the regulation of cell signaling pathways related to cell adhesion, migration, and invasion. It has been shown to interact with several cell adhesion molecules, including E-cadherin and N-cadherin, and has been shown to play a role in the regulation of cell migration and invasion.

PHLPP2-ALZ1 is also involved in the regulation of cellular processes related to inflammation and stress responses. It has been shown to interact with several stress-related proteins, including heat shock protein (HSP)70 and HSP90, and has been shown to play a role in the regulation of cellular stress responses.

Given its involvement in a wide range of cellular processes, PHLPP2-ALZ1 is a potential drug target or biomarker for a variety of diseases. For example, PHLPP2-ALZ1 has been shown to be involved in the development and progression of various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. It has also been shown to be involved in the regulation of cancer cell growth and metastasis.

In addition to its potential clinical applications, PHLPP2-ALZ1 is also an attractive target for research into the underlying mechanisms of various diseases. For example, studies of the regulation of TGF-β activity by PHLPP2-ALZ1 have identified new insights into the complex mechanisms of this critical pathway.

Overall, PHLPP2-ALZ1 is a protein that is involved in a wide range of cellular processes and is thought to play a role in the development and progression of various diseases. As a potential drug target or biomarker, PHLPP2-ALZ1 is a promising target for the study of these conditions. Further research is needed to fully understand its role in these processes and to develop effective therapies for the treatment of diseases associated with its dysfunction.

Protein Name: PH Domain And Leucine Rich Repeat Protein Phosphatase 2

Functions: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606)

The "PHLPP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHLPP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets