pi3k/akt Pathway: P100 Subunit as A Drug Target (G5289)

Target Name: PIK3C3

NCBI ID: G5289

PIK3C3

pi3k/akt Pathway: P100 Subunit as A Drug Target

Phosphatidylinositol 3-kinase (PI3K) is a protein that plays a crucial role in cellular signaling. It is a transmembrane protein that is involved in the signaling pathway known as the PI3K/Akt pathway. This pathway is involved in many cellular processes, including cell growth, differentiation, and survival. There are several kinases that are involved in the PI3K pathway, and the p100 subunit is one of them.

The p100 subunit is a key protein that is involved in the PI3K pathway. It is a 21-kDa protein that is composed of two transmembrane domains and an intracellular domain. The p100 subunit is involved in the regulation of cellular signaling pathways, including the PI3K /Akt pathway.

Drugs that target the p100 subunit have the potential to be useful in treating various diseases. For example, inhibitors of the PI3K/Akt pathway have been shown to be effective in treating cancer, including breast cancer and colorectal cancer. Additionally, inhibitors of the p100 subunits have been shown to be effective in treating neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

The p100 subunit is also a potential biomarker for certain diseases. The PI3K/Akt pathway is involved in many cellular processes, including cell survival and growth. Therefore, changes in the level of the p100 subunit may be an indication of certain diseases. For example , reduced levels of the p100 subunit have been shown to be associated with poor prognosis in patients with pancreatic cancer. Additionally, decreased levels of the p100 subunit have been shown to be associated with decreased levels of brain-derived neurotrophic factor (BDNF) in individuals with Alzheimer's disease.

Structure

The p100 subunit is a 21-kDa protein that is composed of two transmembrane domains and an intracellular domain. The p100 subunit has a unique structure that is characterized by a long N-terminus and a short C-terminus. The N-terminus of the p100 subunit is involved in the formation of the N-end rule, while the C-terminus is involved in the formation of the C-end rule.

The p100 subunit has a unique mechanism of regulation that is characterized by the presence of a G12-loop and a G16-loop. The G12-loop is a regulatory loop that is involved in the regulation of the activity of the p100 subunit. -loop is a structural loop that is involved in the regulation of the stability of the p100 subunit.

biological functions

The p100 subunit is involved in the regulation of various cellular processes, including the PI3K/Akt pathway. This pathway is involved in the regulation of cellular signaling pathways, including cell growth, differentiation, and survival. The p100 subunit is involved in the regulation of the activity of several protein kinases, including AKT1, AKT2, and kinase A.

The p100 subunit is also involved in the regulation of the activity of several transcription factors, including NF-kappa-B and AP-1. These transcription factors are involved in the regulation of cellular signaling pathways, including cell growth, differentiation, and survival.

pharmacological significance

In conclusion, the p100 subunit is a protein that is involved in the PI3K/Akt pathway. It is a 21-kDa protein that is composed of two transmembrane domains and an intracellular domain. The p100 subunit has a unique structure that is characterized by a long N-terminus and a short C-terminus. The p100 subunit is involved in the regulation of various cellular

Protein Name: Phosphatidylinositol 3-kinase Catalytic Subunit Type 3

Functions: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:7628435, PubMed:33637724). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity)

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