Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH): A Potential Drug Target and Biomarker

Target Name: PIGH

NCBI ID: G5283

PIGH

Other Name(s): Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (isoform 1) | PIGH variant 1 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H | phosphatidylinositol glycan anchor biosynthesis class H | phosphatidylinositol N-acetylglucosaminyltransferase subunit H | Phosphatidylinositol-glycan biosynthesis class H protein | PIG-H | GPI-H | phosphatidylinositol-glycan biosynthesis class H protein | Phosphatidylinositol glycan anchor biosynthesis class H, transcript variant 1 | phosphatidylinositol-glycan biosynthesis, class H protein | phosphatidylinositol glycan, class H | PIGH_HUMAN

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH): A Potential Drug Target and Biomarker

Phosphatidylinositol (PI) is a key signaling molecule in various cellular processes, including cell signaling, inflammation, and metabolism. The PI system plays a crucial role in maintaining cellular homeostasis and functions, and numerous dysregulations in PI levels have been implicated in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. The PI system is also a promising target for drug development due to its unique structure and function. One of the PI signaling pathways, PI-N-acetylglucosaminyltransferase (PIGN), has been identified as a potential drug target and biomarker. In this article, we will discuss PIGN and its functions, as well as its potential as a drug target.

PIGN: The N-Acetyl Glucosaminyl Transferase

PIGN is a key enzyme in the PI signaling pathway that adds an acetyl group to the N-acetylglucosaminyl group on the surface of PI molecules. This modification plays a crucial role in maintaining the stability and integrity of PI signaling intermediates and has been implicated in various cellular processes, including cell signaling, inflammation, and metabolism.

PIGN is a protein that consists of 21 kDa of amino acids and has a unique structure that includes a catalytic core and a transmembrane region. The catalytic core consists of a catalytic domain and a hypervariable region (HVR), which is responsible for the acetylation reaction. The HVR is a variable region that is unique to each PIGN isoform and allows for the specific acetylation of different PI molecules.

Function and Dysregulation

The PI system plays a crucial role in maintaining cellular homeostasis and functions, and dysregulations in PI levels have been implicated in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. PIGN is involved in several cellular processes, including cell signaling, cell division, and inflammation.

In cell signaling, PIGN is involved in the regulation of cell proliferation, apoptosis, and angiogenesis. PIGN has been shown to be involved in the regulation of cell cycle progression, where it promotes the G1 phase and inhibits the S phase, which are critical for cell growth and proliferation. PIGN has also been shown to be involved in the regulation of apoptosis, where it promotes the production of pro-apoptotic transcription factors and inhibits the production of anti-apoptotic transcription factors, which are critical for cell survival.

In inflammation, PIGN has been shown to play a crucial role in the regulation of immune responses and tissue repair. PIGN has been shown to be involved in the regulation of T cell development and function, where it promotes the production of regulatory T cells and inhibits the production of memory T cells, which are critical for immune responses.

Dysregulation of PIGN has been implicated in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, PIGN has been shown to be involved in the development and progression of neurobladder cancer, where it promotes the growth and survival of neurobladder cancer cells. PIGN has also been shown to be involved in the development and progression of Alzheimer's disease, where it promotes the formation of neurofibrillary tangles and inhibits the production of neurogenic factors, which are critical for neurodegenerative diseases.

PIGN as a Drug Target

PIGN has been identified as a potential drug target due to its unique structure and function. The acetylation of PI molecules by PIGN is a critical step in the PI signaling pathway, and targeting

Protein Name: Phosphatidylinositol Glycan Anchor Biosynthesis Class H

Functions: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis

The "PIGH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PIGH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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