PHOX2B: A Potential Drug Target for Neuroblastomas (G8929)

Target Name: PHOX2B

NCBI ID: G8929

PHOX2B

PHOX2B: A Potential Drug Target for Neuroblastomas

PHOX2B, also known as neuroblastoma Phox, is a protein that is expressed in a variety of tissues, including the brain, and is known to play a role in the development and progression of neuroblastomas. While more research is needed to fully understand its role, PHOX2B has potential as a drug target or biomarker in the treatment of neuroblastomas.

Neuroblastomas are a type of cancer that arises from neural stem cells, which are responsible for the development and maintenance of all of the tissues in the nervous system. When these stem cells divide out of control, they can form a neuroblastoma. Treatment for neuroblastomas is often difficult and effective, with a five-year survival rate of only around 15%.

One potential approach to treating neuroblastomas is to target the PHOX2B protein. PHOX2B is a transcription factor that has been shown to play a role in the development and progression of neuroblastomas. It has been shown to promote the expression of genes that are involved in cell proliferation and survival, and has been linked to the development of neuroblastoma.

In addition, PHOX2B has also been shown to play a role in the regulation of pain. It has been shown to reduce the sensitivity to pain in animals with neuroblastomas, and has been linked to the development of neuroblastoma in animal models of pain.

Furthermore, PHOX2B has also been shown to play a role in the regulation of stem cell proliferation. It has been shown to inhibit the proliferation of stem cells, which may have implications for the development and treatment of neuroblastomas.

In conclusion, PHOX2B is a protein that has potential as a drug target or biomarker in the treatment of neuroblastomas. Further research is needed to fully understand its role and to develop effective treatments.

Protein Name: Paired Like Homeobox 2B

Functions: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element

The "PHOX2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHOX2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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