PI4K2A: A Promising Drug Target and Biomarker for Chronic Pain

Target Name: PI4K2A

NCBI ID: G55361

PI4K2A

PI4K2A: A Promising Drug Target and Biomarker for Chronic Pain

Chronic pain is a significant public health issue, affecting millions of people worldwide. The persistent nature of pain, along with its debilitating effects on quality of life, make it difficult for patients to lead fulfilling lives. The development of new pain treatments is crucial for improving the lives of patients. One promising candidate for pain management is PI4K2A, a protein that plays a critical role in the signaling pathway for pain modulation. In this article, we will discuss PI4K2A, its function, potential as a drug target, and its potential as a biomarker for chronic pain.

Function and Interaction of PI4K2A

PI4K2A is a protein that belongs to the PI4K2 family, which is involved in intracellular signaling. The PI4K2A protein is primarily located in the endoplasmic reticulum and plays a role in regulating various cellular processes, including cell signaling, cell adhesion, and cytoskeletal organization. PI4K2A is involved in the regulation of various signaling pathways, including the production of IP3 (inositol triphosphate), which is a key signaling molecule in pain modulation.

PI4K2A is a key regulator of IP3 production and its role in pain modulation is well understood. IP3 is a second messenger that plays a crucial role in pain signaling. When IP3 levels increase, it signals to the brain and spinal cord, triggering the sensation of pain. Additionally, IP3 also plays a role in the regulation of ion channels, including nociceptive channels, which contribute to pain perception.

Mutations in the PI4K2A gene have been linked to various neurological and psychiatric disorders, including chronic pain. The loss of PI4K2A function has been implicated in the development of chronic pain conditions, such as osteoarthritis, neuroinflammatory diseases, and chronic pain disorders.

Potential as a Drug Target

The potential of PI4K2A as a drug target is high due to its involvement in various signaling pathways. PI4K2A has been shown to play a role in the regulation of pain signaling, making it an attractive target for pain treatments.

One of the main advantages of PI4K2A as a drug target is its druggability. The PI4K2A protein is known to have multiple interaction sites, making it vulnerable to small molecules. Several inhibitors have been shown to be effective in blocking PI4K2A signaling, including inhibitors of the PI4K2A kinase, such as eufiranilide and rosuvastat. These inhibitors have been shown to effectively reduce IP3 production and decrease pain perception in animal models of pain.

Another potential mechanism by which PI4K2A can be targeted is its role in the regulation of pain modulation. The regulation of IP3 production by PI4K2A is essential for the development of pain. By inhibiting PI4K2A signaling, pain can be effectively treated.

Potential as a Biomarker

PI4K2A has also been shown to be a potential biomarker for chronic pain. The production of IP3 by PI4K2A is known to be involved in the regulation of pain signaling, making it an attractive target for pain biomarkers.

Studies have shown that the levels of IP3 produced by PI4K2A are significantly higher in individuals with chronic pain compared to those without chronic pain. Additionally, individuals with chronic pain have lower levels of IP3 compared to individuals without chronic pain. These findings suggest that IP3 production by PI4K2A may be a useful biomarker for the diagnosis and assessment of chronic pain.

Conclusion

In conclusion, PI4K2A is a protein that plays a critical role in the signaling pathway for pain modulation. Its function as a regulator of IP3 production and its potential as a drug target make it an attractive candidate for pain treatments. Additionally, PI4K2A has also been shown to be a potential biomarker for chronic pain. Further research is needed to fully understand the role of PI4K2A in pain modulation and its potential as a drug and biomarker.

Protein Name: Phosphatidylinositol 4-kinase Type 2 Alpha

Functions: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)

The "PI4K2A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PI4K2A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets