A Potential Drug Target: PIEZO1, a Family with Sequence Similarity 38, Member A

Target Name: PIEZO1

NCBI ID: G9780

PIEZO1

A Potential Drug Target: PIEZO1, a Family with Sequence Similarity 38, Member A

Piezoelectric materials have been found to be an attractive option for drug development due to their unique properties, such as high hearability, low cost, and biocompatibility. Among the various piezoelectric materials, PIEZO1, family with sequence similarity 38 (P1), has garnered significant interest due to its unique structure and biochemical properties. This article will explore the potential drug target status of P1 and its implications for future research.

Structure and PIEZO1's Properties

PIEZO1 is a member of the PIEZO family, which is known for producing high-quality piezoelectric materials. The PIEZO family is characterized by the presence of a single transmembrane protein, Z (Zn2+) and a unique 尾-sheet structure. Z is involved in the generation of the piezoelectric charge, while the 尾-sheet plays a crucial role in maintaining the stability of the Zn2+ ion.

PIEZO1 has several unique properties that make it an attractive drug target. Its high hearability, low cost, and biocompatibility make it an ideal material for various applications, including medical devices, wearables, and consumer electronics. Additionally, its unique 尾-sheet structure and the involvement of Zn2+ ions make it a potential drug target for various diseases, including heart failure, epilepsy, and diabetes.

Drug Target Status and Potential Therapeutic Applications

The potential drug target status of PIEZO1 is high, as its unique properties and structure make it an attractive target for various diseases. Several studies have investigated the potential therapeutic applications of PIEZO1, including its potential as a drug delivery system for anti-inflammatory agents and its potential as a therapy for heart failure.

One of the most promising potential therapeutic applications of PIEZO1 is its potential as a drug delivery system for anti-inflammatory agents. PIEZO1 has been shown to have a high affinity for both Zn2+ and other metal ions, making it an ideal material for drug delivery systems. Several studies have demonstrated that PIEZO1 can effectively deliver anti-inflammatory agents, such as corticosteroids, to the site of inflammation, leading to reduced inflammation and improved patient outcomes.

Another promising potential therapeutic application of PIEZO1 is its potential as a therapy for heart failure. PIEZO1 has been shown to have a unique mechanical properties that can improve the contractility of heart cells, leading to improved heart function and reduced symptoms of heart failure. Additionally, PIEZO1 has been shown to have a high hearability, which is essential for ensuring that the therapy is effective.

In conclusion, the potential drug target status of PIEZO1, family with sequence similarity 38 (P1), is high due to its unique properties and structure. Its high hearability, low cost, and biocompatibility make it an ideal material for various applications, including medical devices, wearables, and consumer electronics. Additionally, its unique 尾-sheet structure and the involvement of Zn2+ ions make it a potential drug target for various diseases, including heart failure, epilepsy, and diabetes. Further research is needed to fully understand the potential therapeutic applications of PIEZO1 and to develop safe and effective drugs that target this protein.

Protein Name: Piezo Type Mechanosensitive Ion Channel Component 1

Functions: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation

The "PIEZO1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PIEZO1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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