EPB41L3: A Unique Protein with A Band 4.1 Like Structure and Expression Pattern in Erythrocytes

Target Name: EPB41L3

NCBI ID: G23136

EPB41L3

EPB41L3: A Unique Protein with A Band 4.1 Like Structure and Expression Pattern in Erythrocytes

EPB41L3, also known as Erythrocyte membrane protein band 4.1 like 3, is a protein that is expressed in the erythrocytes, which are responsible for carrying oxygen in the blood. This protein is of interest as a potential drug target or biomarker due to its unique structure and expression pattern.

The protein encoded by the EPB41L3 gene is a 194 amino acid long protein that belongs to the superfamily of cytoplasmic proteins known as the band 4.1 like proteins. These proteins are characterized by the presence of a transmembrane region, a cytoplasmic region, and a terminal region that is involved in various cellular processes. The cytoplasmic region of EPB41L3 contains a unique feature that is not found in other band 4.1 like proteins, known as a long terminal coiled structure.

The long terminal coiled structure is a type of protein structure that is characterized by a closed loop of amino acids that can be derived from the amino acids at the end of the protein. This structure is formed by the positively charged amino acids at the end of the protein, which draw other negatively charged amino acids towards them. The long terminal coiled structure provides a mechanism for the protein to adopt a specific 3D shape and can influence various cellular processes.

EPB41L3 is expressed in the erythrocytes, which are responsible for oxygen carrying in the blood. The erythrocytes are specialized cells that have a unique structure that is optimized for the delivery of oxygen. The endoplasmic reticulum (ER) is the main organel of the cell that synthesizes and stores proteins, and it is surrounded by the periblast, which is a thin layer of cells that surround the ER. The erythrocytes have a unique relationship with the ER and the periblast, and it is thought that this relationship may be related to the function of EPB41L3.

One of the unique features of EPB41L3 is its expression pattern. The protein is mainly expressed in the erythrocytes, but it is also expressed in the endothelial cells, which are responsible for forming the blood vessels. This suggests that EPB41L3 may be involved in the regulation of cellular processes that are specific to the erythrocytes and the endothelial cells.

The function of EPB41L3 is not well understood, but it is thought to be involved in the regulation of various cellular processes that are specific to the erythrocytes and the endothelial cells. The protein may be involved in the regulation of oxygen transport in the blood, the maintenance of the cell's shape, and the regulation of the cytoskeleton.

In conclusion, EPB41L3 is a unique protein that is characterized by its long terminal coiled structure and its expression pattern. The protein is expressed in the erythrocytes and endothelial cells, and its function is not well understood. Further research is needed to determine the exact function of EPB41L3 and its potential as a drug target or biomarker.

Protein Name: Erythrocyte Membrane Protein Band 4.1 Like 3

Functions: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5

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