AOC2: A Potential Drug Target and Biomarker for Copper-Containing Enzymes

Target Name: AOC2

NCBI ID: G314

AOC2

AOC2: A Potential Drug Target and Biomarker for Copper-Containing Enzymes

Amine oxidase (AO)2, also known as copper-containing 2 (retina-specific), is a subunit of the AO enzyme family that plays a crucial role in the processing of amines, such as histidine and tyrosine, in the retina.1 AO2 is highly specific for copper ions, which are essential for its catalytic activity.2 The human retina is the only tissue in the body where AO2 is present, and its function is essential for vision.3 Therefore, any changes in AO2 function have been linked to various eye diseases, including age-related macular degeneration (AMD),4 cataracts, and age-related lens opacities.5

Despite the significant impact of AO2 on human vision, its dysfunction has not been fully understood. The available research has shown that AO2 dysfunction is associated with the development of age-related diseases, but the underlying mechanisms are not well understood.6

Targeting AO2: A Potential Drug Pathway

The development of new treatments for age-related diseases is a major focus of research in the field of aging.7 One potential approach to targeting AO2 is to develop drugs that inhibit its activity.8

Several studies have identified potential drug targets for AO2, including the interaction with protein tyrosine kinase (PTK) signaling pathways,9 which are involved in cell growth, survival, and angiogenesis.10,11

In addition, several studies have identified potential biomarkers for AO2 dysfunction, including the level of AO2 in retinal tissues,12 the activity of AO2 in cell culture models of AO2 dysfunction,13 and the expression of AO2-related genes in eye tissues and mouse models of AO2 dysfunction.14

AOC2 as a Drug Target: Implications for the Treatment of Age-Related Diseases

In summary, AOC2 is a protein that plays a crucial role in the processing of amines in the retina. Its dysfunction is associated with the development of age-related diseases, including AMD, cataracts, and age-related lens opacities. Several studies have identified potential drug targets for AO2, including the interaction with PTK signaling pathways, and potential biomarkers for AO2 dysfunction. Therefore, targeting AO2 with drugs that inhibit its activity or modulate its expression levels could be a promising approach to treating age-related diseases.

Conclusion

In conclusion, AOC2 is a protein that plays a critical role in the processing of amines in the retina. Its dysfunction is associated with the development of age-related diseases, including AMD, cataracts, and age-related lens opacities. Developing drugs that inhibit AO2 activity or modulate its expression levels could be a promising approach to treating age-related diseases. Further research is needed to fully understand the mechanisms of AO2 dysfunction and to develop effective treatments.

Protein Name: Amine Oxidase Copper Containing 2

Functions: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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