GABA(A) receptor pi subunit: a drug target and biomarker (G2568)

Target Name: GABRP

NCBI ID: G2568

GABRP

GABA(A) receptor pi subunit: a drug target and biomarker

GABA(A) receptor pi subunit (GABA(A)Rp) is a protein that plays a crucial role in the regulation of neural circuits in the brain. GABA is a neurotransmitter that has calming and inhibitory effects, and its levels are often reduced in certain neurological disorders. The GABA(A) receptor pi subunit is a key protein that helps to maintain the normal function of GABA receptors. However, research has also shown that GABA(A)Rp can be involved in the development and progression of certain neurological disorders. conditions. As a result, GABA(A)Rp has emerged as a potential drug target and biomarker for a variety of neurological disorders.

GABA(A)Rp is a transmembrane protein that is expressed in many different tissues, including brain, heart, and pancreas. It is a component of the GABA(A) receptor, which is a type of ion channel that plays a central role in the regulation of neurotransmitter signaling. The GABA(A) receptor is composed of two subunits: the GABA(A) receptor alpha subunit (伪2) and the GABA(A) receptor beta subunit (尾2). The alpha subunit is responsible for the catalytic activity of the receptor, while the beta subunit is responsible for the regulation of the receptor's dynamics.

GABA(A)Rp is a 120-kDa protein that is composed of 11 transmembrane伪 helices, 2 N-cysteine 鈥嬧?媟esidues, and a C-terminus. It is expressed in the brain and other nervous tissue and plays a critical role in the regulation of GABA signaling. GABA is a neurotransmitter that has inhibitory effects on a wide range of neural circuits, including those involved in movement, sensory processing, and learning. The levels of GABA in the brain are often reduced in certain neurological disorders, such as Alzheimer's disease, Parkinson's disease, and chronic pain.

GABA(A)Rp is involved in the regulation of GABA signaling by several different mechanisms. One of the most well-known is its role in the regulation of GABA receptor stability. GABA(A)Rp is known to play a role in the assembly and disassembly of GABA receptors, which is important for the regulation of their stability and the trafficking of GABA across the membrane. Additionally, GABA(A)Rp is involved in the regulation of GABA receptor function by modulating the activity of GABA-gated channels, which are involved in the rapid depolarization of the receptor that is caused by GABA binding.

GABA(A)Rp is also involved in the regulation of GABA signaling by modulating the activity of GABA-activated channels, which are involved in the rapid hyperpolarization of the receptor that is caused by GABA binding. These channels are critical for the regulation of a wide range of neural circuits, including those involved in movement, sensory processing, and learning.

GABA(A)Rp is a potential drug target because of its involvement in the regulation of GABA signaling. Studies have shown that GABA(A)Rp is downregulated in the brains of individuals with certain neurological disorders, and that this downregulation is associated with the development of certain neurological symptoms. For example, individuals with Alzheimer's disease have lower levels of GABA(A)Rp in their brains, and this is thought to contribute to the development of the disease. Additionally, GABA(A)Rp is also downregulated in the brains of individuals with certain

Protein Name: Gamma-aminobutyric Acid Type A Receptor Subunit Pi

Functions: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone

The "GABRP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GABRP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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