TAS2R45: A GPR59 Drug Target and Potential Biomarker (G259291)

Target Name: TAS2R45

NCBI ID: G259291

TAS2R45

TAS2R45: A GPR59 Drug Target and Potential Biomarker

Introduction

G-protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPR59, a GPCR, is a potential drug target and biomarker for various diseases. In this article, we will discuss TAS2R45, a GPR59 receptor, its potential as a drug target and biomarker, and its current research status.

GPR59 Receptor: Structural and Functional Characterization

GPR59 is a 7-transmembrane GPCR that is expressed in various tissues, including brain, heart, skeletal muscles, and regulatory organs. It consists of an extracellular loop, a transmembrane segment, and an intramembrane segment. The transmembrane segment consists of four伪 helices and Three 尾 rings form a helix-尾 structure. GPR59 receptor agonists can cause a variety of physiological effects, such as vasoconstriction, increased heart rate, and neuronal activity.

TAS2R45: A Unique GPR59 Receptor

TAS2R45 is a GPR59 receptor antagonist synthesized by researchers at the University of Tokyo, Japan. TAS2R45 has the following features:

1. Selectivity: TAS2R45 can selectively antagonize GPR59 receptors without affecting other GPCRs.
2. Affinity: The affinity of TAS2R45 is significantly higher than that of GPR59, and it can effectively antagonize the GPR59 receptor.
3. Safety: TAS2R45 shows no toxicity in vivo or in vitro, which provides support for its use as a drug target in drug research.

Effects of TAS2R45 on the nervous system

The impact of TAS2R45 on the nervous system is mainly reflected in the treatment of neurological diseases. TAS2R45 can reduce the excitability of neurons, thereby reducing neuronal damage. In neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, TAS2R45 can play a role in alleviating symptoms and improving neuronal function.

Effects of TAS2R45 on the cardiovascular system

TAS2R45 can also affect the cardiovascular system. TAS2R45 can dilate blood vessels and lower blood pressure, thereby reducing the risk of cardiovascular disease. In addition, TAS2R45 can also regulate cardiac rhythm and improve cardiac function.

Biological activity of TAS2R45

TAS2R45 has a variety of biological activities. TAS2R45 can bind to the GPR59 receptor, thereby antagonizing the function of this receptor. TAS2R45 can also stimulate neuronal apoptosis, thus playing an anti-neuronal damage role. In addition, TAS2R45 can also regulate the function of immune cells and participate in immune response and immune balance.

Clinical application prospects of TAS2R45

As a GPR59 receptor antagonist, TAS2R45 has great clinical application prospects. TAS2R45 could be used to treat neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. TAS2R45 may also be used to treat cardiovascular diseases such as hypertension and cardiac arrhythmias. In addition, TAS2R45 can also be used to treat immune-related diseases, such as autoimmune diseases and immunodeficiency diseases.

Conclusion

TAS2R45 is a GPR59 receptor antagonist with great potential. TAS2R45 has characteristics such as selectivity, affinity, safety and biological activity, which provide good support for its use as a drug target in drug research and clinical applications. Future studies can further explore the mechanism of action of TAS2R45 and provide more evidence for its use as a drug target.

Protein Name: Taste 2 Receptor Member 45

Functions: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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