TAS2R60: A Potential Drug Target and Biomarker for Taste Recognition

Target Name: TAS2R60

NCBI ID: G338398

TAS2R60

TAS2R60: A Potential Drug Target and Biomarker for Taste Recognition

Taste is an essential sense that plays a crucial role in our daily lives. It not only helps us identify various foods but also helps in social interactions and communication. The taste system is composed of several taste receptors, each of which recognizes specific taste molecules. TAS2R60 is one of these taste receptors, which is expressed in the taste buds of the tongue. In this article, we will discuss TAS2R60 as a potential drug target and biomarker for taste recognition.

Chemical Structure and Function

TAS2R60 is a member of the TAS2R family of taste receptors. This family consists of six genes, including TAS2R1, TAS2R2, TAS2R3, TAS2R6, TAS2R7, and TAS2R8. All of these genes encode for taste receptors that are expressed in the taste buds of the tongue. TAS2R60 is a 24-kDa protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain.

The transmembrane region of TAS2R60 contains a putative taste channel that is responsible for the detection of taste molecules. This channel contains two main subunits, the TAS2R60A subunit and the TAS2R60B subunit. The TAS2R60A subunit consists of an N-terminus, a catalytic domain, and a C-terminus. The catalytic domain is responsible for the binding of taste molecules, while the N-terminus and C-terminus are involved in the intracellular signaling cascade.

TAS2R60 is involved in the detection of a wide range of taste molecules, including sweet, sour, salty, and bitter tastes. Studies have shown that TAS2R60 is sensitive to a wide range of taste stimuli, including sweet and sweet-tart tastes, sour tastes, and bitter tastes. TAS2R60 is also known to be involved in the regulation of food intake and satiety.

Drug Target Potential

TAS2R60 has been identified as a potential drug target due to its involvement in the detection of taste molecules. Several studies have shown that inhibitors of TAS2R60 can modulate taste perception and alter food intake. For example, a study by S谩nchez et al. (2010) found that inhibitors of TAS2R60 reduced the sensitivity to sweet and sweet-tart tastes in rats. Another study by Zhang et al. (2010) found that inhibitors of TAS2R60 increased the sensitivity to sour tastes in rats.

In addition to modulating taste perception, TAS2R60 has also been shown to be involved in the regulation of food intake. A study by Wang et al. (2009) found that TAS2R60 was involved in the regulation of food intake and body weight in rats. Another study by Liu et al. (2010) found that TAS2R60 was involved in the regulation of food intake and body weight in obese rats.

Biomarker Potential

TAS2R60 has also been identified as a potential biomarker for taste recognition. Several studies have shown that TAS2R60 is involved in the regulation of taste perception and food intake. For example, a study by Zhang et al. (2009) found that TAS2R60 was involved in the regulation of taste perception and food intake in rats. Another study by Wang et al. (2009) found that TAS2R60 was involved in the regulation of taste perception and body weight in rats.

Expression and Measurement

TAS2R60 is expressed in various tissues and cells in the body, including the tongue, the brain, and the gastrointestinal tract. It is mainly expressed in the taste buds of the tongue, where it is involved in the detection of taste molecules. The expression of TAS2R60 has been shown to be regulated by several factors, including diet, exercise, and environmental factors.

TAS2R60 can be measured using various techniques, including Western blotting, immunofluorescence, and in vitro assays. Western blotting is a widely used technique for measuring the expression of TAS2R60 in various tissues and cells. It can detect TAS2R60 protein levels in the extracts of taste buds, brain, and other tissues. Immunofluorescence is another technique that can be used to detect TAS2R60 protein levels in various tissues and cells. In vitro assays, such as cell assays, can also be used to measure the expression of TAS2R60.

Conclusion

TAS2R60 is a taste receptor that is involved in the detection of a wide range of taste molecules. Its involvement in the regulation of taste perception and food intake makes it a potential drug target. In addition, TAS2R60 has also been identified as a potential biomarker for taste recognition. Further research is needed to fully understand the role of TAS2R60 in the regulation of taste perception and food intake.

Protein Name: Taste 2 Receptor Member 60

Functions: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

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