C2CD3: A Promising Drug Target and Potential Biomarker for Centriole Elongation in Cancer

Target Name: C2CD3

NCBI ID: G26005

C2CD3

C2CD3: A Promising Drug Target and Potential Biomarker for Centriole Elongation in Cancer

Introduction

Centriole elongation is a critical process in the cell division cycle, where the number of daughter cells produced is determined by spindle length. In mitosis, the spindle is composed of two centrioles and fibers. Among them, fibers are made of protein aggregates, while centrioles are made of tubulin. During anaphase of mitosis, centrioles and fibers shorten and then separate, ensuring that each new cell receives a complete set of chromosomes.

C2CD3 is a protein found in the mitotic spindle. Its scientific name is C2 domain containing 3 centriole elongation regulator. The short arm of C2CD3 contains a single-chain domain, and the long arm consists of two domains, including the D1 and D2 domains. The D1 domain includes a short 伪-helix and a large 伪-helix, while the D2 domain includes an 伪-helix and a 尾-coil.

Function of C2CD3

C2CD3 is part of the spindle tubulin complex. During the early stages of mitosis, tubulin is formed at the poles of the cell and is then used by the spindle to assemble chromosomes onto spindle fibers. During anaphase of mitosis, tubulin shortens and then separates, ensuring that each new cell receives a complete set of chromosomes.

The functions of C2CD3 are mainly reflected in the following aspects:

1. Affect the length of spindle fibers

C2CD3 is an important component of the spindle tubulin complex, which controls spindle formation by regulating the length of spindle fibers. In the early stages of mitosis, C2CD3 binds to spindle tubulin, thereby inhibiting tubulin polymerization and making spindle fibers shorter and thicker. In the late stages of mitosis, C2CD3 promotes the polymerization of tubulin, making spindle fibers long and thin.

2. Participate in chromosome segregation

C2CD3 is also an important component involved in chromosome segregation. During the late stages of mitosis, C2CD3 binds to the D1 domain of the spindle, causing the chromosomes on the spindle fibers to separate and distribute evenly into the two daughter cells.

3. Fight spindle depolymerization

During late mitosis, C2CD3 also interacts with other tubulin proteins in the spindle, thereby inhibiting spindle depolymerization. This helps maintain the structural and functional integrity of the spindle, thereby ensuring that chromosomes are efficiently distributed during segregation.

4. Participate in the mitotic cycle

C2CD3 plays an important role in the mitotic cycle. It participates in various stages such as spindle formation, chromosome segregation, and spindle depolymerization. At the same time, C2CD3 also plays a role in other stages of the mitotic cycle. For example, in the prophase of mitosis, C2CD3 will bind to the tubulin of the spindle, thereby promoting the formation of the spindle.

The role of C2CD3

As an important protein, C2CD3 plays an important role in the mitosis process. Its role is mainly reflected in the following aspects:

1. Affect the length of spindle fibers

C2CD3 is an important component of the spindle tubulin complex, which controls spindle formation by regulating the length of spindle fibers. In the early stages of mitosis, C2CD3 binds to spindle tubulin, thereby inhibiting tubulin polymerization and making spindle fibers shorter and thicker. In the late stages of mitosis, C2CD3 promotes the polymerization of tubulin, making spindle fibers long and thin.

2. Participate in chromosome segregation

C2CD3 is also an important component involved in chromosome segregation. During the late stages of mitosis, C2CD3 binds to the D1 domain of the spindle, causing the chromosomes on the spindle fibers to separate and distribute evenly into the two daughter cells.

3. Fight spindle depolymerization

During late mitosis, C2CD3 interacts with other tubulin proteins in the spindle, thereby inhibiting spindle depolymerization. This helps maintain the structural and functional integrity of the spindle, thereby ensuring that chromosomes are efficiently distributed during segregation.

4. Participate in the mitotic cycle

C2CD3 plays an important role in the mitotic cycle. It participates in various stages such as spindle formation, chromosome segregation, and spindle depolymerization. At the same time, C2CD3 also plays a role in other stages of the mitotic cycle. For example, in the prophase of mitosis, C2CD3 will bind to the tubulin of the spindle, thereby promoting the formation of the spindle.

potential drug targets

As an important protein, C2CD3 has great potential in biomedical research. Because C2CD3 plays an important role in the mitosis process, scientists are exploring C2CD3 as a potential drug target.

At present, C2CD3 has been proven to have strong pharmacological activity. Studies have shown that C2CD3 can inhibit the spindle formation of tumor cells, thereby leading to chromosomal instability in tumor cells and increasing the risk of tumor cell apoptosis. In addition, C2CD3 can also inhibit the spindle depolymerization of tumor cells, thereby leading to chromosomal instability in tumor cells and increasing the risk of tumor cell apoptosis.

In the future, C2CD3 may become an important drug target for the treatment of various cancers. However, the current research on C2CD3 is still in its preliminary stage, and further in-depth research is needed to better understand its pharmacological effects and provide scientific basis for clinical application.

Protein Name: C2 Domain Containing 3 Centriole Elongation Regulator

Functions: Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3

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