Understanding The Potential Role of C5AR1 in Cancer Development

Target Name: C5AR1

NCBI ID: G728

C5AR1

Understanding The Potential Role of C5AR1 in Cancer Development

C5AR1, also known as C5R1, is a protein that is expressed in the human placenta and has been shown to play a role in the development and maintenance of cancer. The Placenta is a vital organ that supports the growth and development of fetuses, and it is often used as a model for studying the effects of drugs on cancer progression.

C5AR1 is a member of the C5 family of proteins, which are known for their role in cell signaling. The C5 family of proteins includes several different isoforms, each of which has distinct differences in its localization and function. C5AR1 is a type of C5 protein that is predominantly expressed in the placenta, as its name suggests.

The role of C5AR1 in cancer development and progression is still being fully understood, but it is clear that it plays an important role. Several studies have shown that high levels of C5AR1 are associated with poor prognosis in cancer patients. For example, a study published in the journal PLoS Medicine found that individuals with high C5AR1 levels were more likely to have locally advanced or metastatic breast cancer, which is a common type of cancer that is difficult to treat.

In addition to its potential role in cancer, C5AR1 is also being studied as a potential drug target. The C5AR1 protein has been shown to interact with several different signaling pathways, which makes it an attractive target for small molecules. In fact, several companies have already filed patents for drugs that target C5AR1, which could be used to treat a variety of diseases, including cancer.

One of the challenges in studying C5AR1 as a drug target is its complex structure. C5AR1 is a large protein that is composed of several different domains, including an extracellular domain, a transmembrane domain, and an intracellular domain. These domains give C5AR1 its unique structure and function, and they can be targeted by small molecules with different properties.

To study C5AR1 as a drug target, researchers have used a variety of techniques to investigate its properties. One of the most common methods is mass spectrometry, which is a technique that allows researchers to identify the different proteins that make up a sample and to quantify the levels of each protein. By analyzing the mass spectrometry results, researchers can learn more about the structure and function of C5AR1.

Another approach that researchers have used to study C5AR1 is to use cell-based assays. These assays allow researchers to study the behavior of cells in a controlled environment and to identify the effects of drugs on cell behavior. By using these assays, researchers can gain insights into the mechanisms of action of drugs on C5AR1 and its role in cancer development and progression.

In addition to these techniques, researchers have also used computational tools to study C5AR1. These tools allow researchers to predict the structure and function of C5AR1 based on its amino acid sequence, and to use this information to identify potential drug targets. By using these tools, researchers can identify several potential targets for C5AR1, including some that have already been patented by several companies.

Overall, C5AR1 is a protein that has great potential as a drug target. Its complex structure and the fact that it is expressed in the placenta make it an attractive target for small molecules, and several companies have already filed patents for drugs that target C5AR1. Further research is needed to fully understand the role of C5AR1 in cancer development and progression, and to identify safe and effective drugs that can be used to treat this disease.

Protein Name: Complement C5a Receptor 1

Functions: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520)

The "C5AR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about C5AR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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