Unlocking the Potential of C5orf34: A Drug Target and Biomarker for Chromosome 5

Target Name: C5orf34

NCBI ID: G375444

C5orf34

Other Name(s): Chromosome 5 open reading frame 34 | chromosome 5 open reading frame 34 | CE034_HUMAN | Uncharacterized protein C5orf34

Unlocking the Potential of C5orf34: A Drug Target and Biomarker for Chromosome 5

Introduction

Chromosome 5 is one of the chromosomes that contribute to the human genome, hosting over 1,000 genes. Chromosome 5 open reading frame (ORF) 34 is a gene that has garnered significant attention due to its unique structure and potential involvement in various cellular processes. C5orf34 has been identified as a potential drug target and biomarker for Chromosome 5, providing new insights into the biology of this chromosome and its role in human disease.

The Chromosome 5 Open Reading Frame 34 (C5orf34)

C5orf34 is located on chromosome 5, specifically at position 34. It covers an approximate length of 211 base pairs and has a unique gene structure, with a start codon at position 1 and a stop codon at position 112. The gene has a high degree of homology with other genes on chromosome 5, including the tumor suppressor gene TP53 and the neurodegenerative disorder gene NSIP1.

C5orf34 is involved in various cellular processes that are crucial for human growth and development. Some of its functions include:

1. Cellular signaling and development: C5orf34 is involved in the regulation of cell signaling pathways, which are essential for cell growth, differentiation, and survival. The gene has been shown to play a role in the development and maintenance of neuronal stem cells, as well as in the regulation of stem cell plasticity.
2. Cellular stress response: C5orf34 is involved in the cellular stress response, which is critical for maintaining cellular homeostasis in the face of environmental stressors, such as oxidative stress, inflammation, and radiation.
3. Cellular apoptosis: C5orf34 is involved in the regulation of cell apoptosis, which is a natural process that helps remove damaged or dysfunctional cells from the body.

Potential Drug Target

C5orf34 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. The gene has been shown to play a critical role in the regulation of neuronal stem cells and in the development of neurodegenerative disorders. As such, Several small molecules have been shown to interact with C5orf34 and enhance its function, highlighting its potential as a drug target.

One such small molecule is called trifluorotepurine (TFP), which is a compound that has been shown to inhibit the activity of the enzyme TP53, a tumor suppressor gene that is mutated in many human cancers. TFP has been shown to enhance the inhibition of TP53 by C5orf34, leading to increased TP53 activity and a reduction in cell proliferation.

Another small molecule that has been shown to interact with C5orf34 is called Toyota. It is a plant hormone with anti-tumor and anti-inflammatory effects. It can exert its anti-tumor effects by regulating the cell cycle, inhibiting angiogenesis of tumor cells, and promoting apoptosis of tumor cells.

Biomarker

C5orf34 has also been identified as a potential biomarker for Chromosome 5. The gene has a high degree of homology with the tumor suppressor gene TP53, which is often mutated in many human cancers. As such, C5orf34 has been shown to be a useful biomarker for monitoring the effectiveness of cancer treatments that target TP53.

Conclusion

C5orf34 is a gene on chromosome 5 that has garnered significant attention due to its unique structure and potential involvement in various cellular processes. Its functions have been shown to be critical for

Protein Name: Chromosome 5 Open Reading Frame 34

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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