Unraveling the Potential of C2orf74 as a Drug Target or Biomarker

Target Name: C2orf74

NCBI ID: G339804

C2orf74

Unraveling the Potential of C2orf74 as a Drug Target or Biomarker

C2orf74 is a protein located in the C2 region of the human chromosome 7. It is a 21kDa glycoprotein that plays a crucial role in the regulation of cell adhesion, migration, and invasion. The identification and characterization of C2orf74 as a potential drug target or biomarker has generated significant interest in the scientific community due to its potential implications for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

C2orf74's Unique Features

C2orf74 is characterized by its unique physical and biochemical properties. It is a glycoprotein, which means it consists of both protein and carbohydrate components. Its molecular weight is 21kDa, and it contains 116 amino acid residues. The protein has a highly conserved N-terminus, which is known as the \"intracellular portion,\" and a C-terminus that is involved in its interactions with other proteins.

One of C2orf74's most remarkable features is its ability to interact with various cell adhesion molecules, including cadherins, E-cadherins, and transmembrane proteases. This interaction is critical for the regulation of cell adhesion and migration, which are essential processes in various biological processes, including tissue development, wound healing, and cancer progression.

C2orf74's Role in Cell Adhesion and Migration

C2orf74 is involved in the regulation of cell adhesion and migration through its interaction with various cell adhesion molecules. These molecules are responsible for maintaining the integrity of the intercellular space and cell-cell contacts, which are essential for cell survival and function.

C2orf74's interaction with cadherins is particularly significant, as cadherins are known to play a central role in cell-cell adhesion. The N-terminus of C2orf74 contains a region that is highly conserved and is involved in the interaction with cadherins. This interaction between C2orf74 and cadherins may contribute to the regulation of cell adhesion and the maintenance of tissue architecture during development.

C2orf74's interaction with E-cadherins is also of interest, as E-cadherins are involved in the regulation of cell-cell contacts and play a critical role in the development and maintenance of tissues. The C2orf74's C-terminus has been shown to interact with E-cadherins, which may contribute to the regulation of cell-cell contacts and the maintenance of tissue architecture during development.

C2orf74's Role in Cancer Progression

C2orf74's involvement in cancer progression is an area of ongoing research. The increased expression and clustering of C2orf74 have been observed in various types of cancer, including breast, ovarian, and colorectal cancer. These changes in expression may contribute to the development and progression of these diseases.

C2orf74 has been shown to play a role in the regulation of cell cycle progression, which is a critical process in cancer progression. The C2orf74's N-terminus contains a region that is involved in the regulation of the G1/S transition, which is a critical step in the cell cycle. This may contribute to the regulation of cell proliferation and the development of cancer.

Conclusion

C2orf74 is a unique protein that has been identified as a potential drug target or biomarker due to its unique physical and biochemical properties, its interaction with cell adhesion molecules, and its involvement in the regulation of cell cycle progression. Further research is needed to fully understand the role of C2orf74 in cancer progression and to explore its potential as a drug target or biomarker.

Protein Name: Chromosome 2 Open Reading Frame 74

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