FBXW8: A Potential Drug Target and Biomarker for F-Box and WD-40 Domain Proteins

Target Name: FBXW8

NCBI ID: G26259

FBXW8

FBXW8: A Potential Drug Target and Biomarker for F-Box and WD-40 Domain Proteins

F-box and WD-40 domain proteins are a diverse family of proteins that play critical roles in various cellular processes. These proteins are involved in various cellular processes such as DNA replication, transcription, and protein-protein interactions. FBXW8, a protein encoded by the gene FBXW8, is one of the member of this family. FBXW8 has been shown to have unique functions in various cellular processes, including the regulation of DNA replication and the detoxification of environmental toxins.

The F-box gene is a conserved gene that is involved in the regulation of various cellular processes. The F-box gene encodes a protein that contains a unique F-box domain. This domain is known for its ability to interact with various protein substrates and play a critical role in various cellular processes. The WD-40 domain is a conserved protein that is known for its ability to interact with various transcription factors and play a critical role in the regulation of gene expression.

FBXW8: A Potential Drug Target

FBXW8 has been shown to play a critical role in the regulation of DNA replication. FBXW8 is a component of the machinery that repairs damaged DNA. This protein has been shown to interact with the protein responsible for repairing damaged DNA. This interaction between FBXW8 and DNA repair proteins may be a potential drug target for cancer therapy.

FBXW8 has also been shown to be involved in the detoxification of environmental toxins. These toxins can cause damage to cellular DNA and disrupt the proper functioning of various cellular processes. FBXW8 has been shown to have the ability to remove these toxins from the cell, thereby protecting the cell from damage. This function of FBXW8 may be a potential drug target for environmental toxins.

FBXW8: A Potential Biomarker

FBXW8 has also been shown to be involved in the regulation of gene expression. These proteins can interact with various transcription factors and regulate the translation of RNA into protein. This function of FBXW8 may be a potential biomarker for various diseases.

Conclusion

In conclusion, FBXW8 is a protein that has unique functions in various cellular processes. These functions make it a potential drug target and biomarker. Further research is needed to fully understand the role of FBXW8 in cellular processes and its potential as a drug.

Protein Name: F-box And WD Repeat Domain Containing 8

Functions: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695)

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