MDGA1: A Potential Drug Target and Biomarker for Pain and Neurotransmission
MDGA1: A Potential Drug Target and Biomarker for Pain and Neurotransmission
MDGA1 (FLJ45018) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a critical role in cellular signaling.
MDGA1 is known for its role in the regulation of pain perception and neurotransmitter release. It is expressed in the central nervous system (CNS) and is involved in the modulation of pain signals. MDGA1 has been shown to play a role in the development of chronic pain conditions, such as fibromyalgia and chronic low back pain.
In addition to its role in pain regulation, MDGA1 is also involved in the regulation of neurotransmitter release and neuroendocrine function. It has been shown to play a role in the regulation of dopamine (neurotransmitter) release from the ventral tegmental area (VTA) of the midbrain, which is responsible for the production of motivation and pleasure signals.
MDGA1 is also involved in the regulation of neuroimmune function, which is the interaction between the immune system and the nervous system. It has been shown to play a role in the regulation of pain sensitivity and the modulation of pain responses to stimuli.
MDGA1 is a potential drug target (or biomarker) due to its involvement in multiple physiological processes. Its role in pain regulation makes it a promising target for the development of pain medications. Additionally, its role in neurotransmission and immune function make it potential targets for neuroimaging and diagnostic tools.
MDGA1 is also a good candidate for biomarker discovery. The development of diagnostic tests that can detect changes in MDGA1 levels in response to specific stimuli, such as pain or neurotransmitter release, could be useful for the diagnosis of chronic pain conditions. Additionally, the regulation of MDGA1 expression could be a useful target for the development of therapeutic interventions for neurodegenerative diseases.
MDGA1 is a protein that is expressed in various tissues of the human body, and its role in multiple physiological processes makes it a promising target for drug development and biomarker discovery. Further research is needed to fully understand the function of MDGA1 and its potential as a drug target.
Protein Name: MAM Domain Containing Glycosylphosphatidylinositol Anchor 1
Functions: Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2
The "MDGA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MDGA1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MDGA2 | MDH1 | MDH1B | MDH2 | MDK | MDM1 | MDM2 | MDM4 | MDN1 | MDS2 | ME1 | ME2 | ME3 | MEA1 | MEAF6 | MEAF6P1 | MEAK7 | Mechanoelectrical transducer (MET) channel | Mechanosensitive Ion Channel | MECOM | MECOM-AS1 | MeCP1 histone deacetylase (HDAC) complex | MECP2 | MECR | MED1 | MED10 | MED11 | MED12 | MED12L | MED13 | MED13L | MED14 | MED14P1 | MED15 | MED15P8 | MED16 | MED17 | MED18 | MED19 | MED20 | MED21 | MED22 | MED23 | MED24 | MED25 | MED26 | MED27 | MED28 | MED29 | MED30 | MED31 | MED4 | MED4-AS1 | MED6 | MED7 | MED8 | MED9 | MEDAG | Mediator Complex | Mediator of RNA Polymerase II Transcription | MEF2A | MEF2B | MEF2C | MEF2C-AS1 | MEF2C-AS2 | MEF2D | MEFV | MEG3 | MEG8 | MEG9 | MEGF10 | MEGF11 | MEGF6 | MEGF8 | MEGF9 | MEI1 | MEI4 | MEIG1 | MEIKIN | MEIOB | MEIOC | MEIOSIN | MEIS1 | MEIS1-AS2 | MEIS1-AS3 | MEIS2 | MEIS3 | MEIS3P1 | MEIS3P2 | Melanin | Melanin-concentrating hormone (MCH) receptor | Melanocortin receptor | Melanoma-Associated Antigen | Melatonin receptor | MELK | MELTF | MELTF-AS1 | Membrane-Bound Protein Tyrosine Phosphatases (rPTPs) | Membrane-spanning 4-domains subfamily A member 4A | MEMO1
