MEAF6 Regulates TGF-β Signaling Pathways (G64769)

Target Name: MEAF6

NCBI ID: G64769

MEAF6

MEAF6 Regulates TGF-β Signaling Pathways

MEAF6 (Protein EAF6 Homolog) is a protein that is expressed in various tissues, including the brain, heart, and lungs. It is a member of the EAF domain family, which is known for their role in the regulation of cell signaling pathways.MEAF6 has been shown to play a role in the regulation of several intracellular signaling pathways, including the TGF-β pathway.

The TGF-β pathway is a well-established signaling pathway that plays a crucial role in the development and maintenance of tissues, including tissues such as blood vessels, neurons, and muscles. The TGF-β pathway is activated by the protein TGF-β, which is a transcription factor that can induce the expression of genes involved in cell signaling.

MEAF6 has been shown to be involved in the regulation of TGF-β signaling in several ways. First, MEAF6 has been shown to interact with TGF-β4, which is a key transcription factor that is involved in the TGF-β pathway. This interaction between MEAF6 and TGF-β4 has been shown to play a role in the regulation of cell proliferation and survival.

Second, MEAF6 has been shown to regulate the activity of several TGF-β pathway transcription factors, including SMAD1, SMAD4, and TGF-β2. These transcription factors are involved in the regulation of cell signaling pathways that are important for tissue development and maintenance.

Third, MEAF6 has been shown to play a role in the regulation of the TGF-β pathway in the development of cancer. Several studies have shown that the TGF-β pathway is involved in the development of many types of cancer, including breast, lung, and brain cancer.MEAF6 has been shown to be involved in the regulation of TGF-β signaling in the development of cancer, which may have implications for the development of new cancer therapies.

Overall, MEAF6 is a protein that is involved in the regulation of several intracellular signaling pathways, including the TGF-β pathway. Several studies have shown that MEAF6 plays a role in the regulation of cell proliferation and survival, and its involvement in the TGF-β pathway has implications for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of MEAF6 in the regulation of intracellular signaling pathways and its potential as a drug target or biomarker.

Protein Name: MYST/Esa1 Associated Factor 6

Functions: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358)

The "MEAF6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MEAF6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets