MED23: A Potential Drug Target for Neuronal Signaling and Inflammation

Target Name: MED23

NCBI ID: G9439

MED23

MED23: A Potential Drug Target for Neuronal Signaling and Inflammation

MED23 (MED23-1), also known as KIAA1216, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Kallikrein-related peptidases (KAPs) family, which includes 14 structurally similar proteins that share a common catalytic mechanism. MED23 is of particular interest as a potential drug target due to its unique structure and the involvement of various signaling pathways.

Structure and Function

MED23 is a 120-amino acid protein that contains a single transmembrane region and a cytoplasmic tail. It has a molecular weight of 11.9 kDa and a pre-membrane N-terminus of 21 amino acids. The cytoplasmic tail of MED23 consists of 15 amino acids and is responsible for its stability and localization to various cellular compartments.

MED23 is involved in various signaling pathways, including the regulation of cell adhesion, migration, and invasion. One of the well-documented functions of MED23 is its role in the regulation of neuronal cell-cell adhesion. MED23 has been shown to be involved in the regulation of tight junction formation and the maintenance of neuronal cell-cell adhesion, which is critical for the integrity of neuronal circuits.

Another function of MED23 is its role in the regulation of cell migration and invasion. MED23 has been shown to be involved in the regulation of cell migration and the production of the migratory protein, Alcidonin.

MED23 is also involved in the regulation of inflammation and cellular responses to stress. It has been shown to be involved in the regulation of inflammation and the production of pro-inflammatory cytokines, such as IL-6 and TNF-浼?.

Drug Target Potential

The unique structure of MED23 and its involvement in various signaling pathways make it an attractive drug target. Several studies have investigated the potential of MED23 as a drug target and have shown that it has a potential for modulating various cellular processes, including cell adhesion, migration , and inflammation.

One of the potential drug targets for MED23 is the inhibition of its activity. The neurotransmitter glutamate is a signaling molecule that can interact with MED23 and regulates synaptic transmission between neurons through its interaction with MED23 (5 ). In addition, MED23 also plays an important role in the inflammatory response, therefore, inhibiting the activity of MED23 may help reduce the inflammatory response.

Another potential drug target for MED23 is the modulation of its localization. The cytoplasmic tail of MED23 can interact with various intracellular structures, including the actin filaments, microtubules, and the endoplasmic reticulum. molecules or antibodies may be an effective way to target its activity.

Conclusion

MED23 is a unique protein that is involved in various signaling pathways and is of particular interest as a potential drug target. Its unique structure and the involvement of various cellular processes make it an attractive target for the development of new therapeutic agents. Further research is needed to fully understand the function of MED23 and its potential as a drug target.

Protein Name: Mediator Complex Subunit 23

Functions: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling

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•   expression level;
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