SNORD102: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Target Name: SNORD102

NCBI ID: G26771

SNORD102

Other Name(s): Small nucleolar RNA, C/D box 102 | small nucleolar RNA, C/D box 102 | RNU102 | Z18

SNORD102: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Small nucleolar RNA (snRNA) is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in eukaryotic cells. One of the key classes of snRNA is C/D box snRNA (CDSN), which are characterized by the presence of a conserved core-consonant-determinant-decorated (CCD) motif and a distal C/D extension. CDSNs are a subset of snRNAs that are predominantly expressed in RNA-protein complexes, where they can interact with protein substrates to regulate protein stability and localization.

SNORD102 is a specific example of a CDSN that has been identified as a potential drug target and biomarker. Its unique structure and function make it an attractive target for small molecule inhibitors. In this article, we will explore the biology of SNORD102, its potential as a drug target, and its potential as a biomarker for various diseases.

SNORD102 Expression and Functions

SNORD102 is a 24.1 kilobase (kb) long RNA molecule that is predominantly expressed in the nuclei of the brain, heart, and testes. It is expressed at levels of 1 to 10 copies per million nuclei (C/M) in brain tissue and heart muscle, and at levels of 1 to 5 copies per million nuclei in muscle tissue. The expression of SNORD102 is highly dependent on the cell type and developmental stage, with lower levels of expression in the liver and spleen.

SNORD102 has been shown to play a role in the regulation of gene expression in various organisms. One of its well-documented functions is to regulate the translation of mRNAs to the ribosome. It has been shown to interact with the protein Snrp, which is involved in the recognition of mRNAs for translation. Additionally, SNORD102 has been shown to interact with the protein stability unit (SSU) of the ribosome, which is involved in the stability of mRNAs during translation.

SNORD102 has also been shown to play a role in the regulation of gene expression in response to various environmental and cellular stressors. For example, it has been shown to be regulated by stress-induced changes in the expression of genes involved in stress response, such as those involved in cell survival and inflammation.

SNORD102 Potential as a Drug Target

SNORD102's unique structure and function make it an attractive target for small molecule inhibitors. The CCDN motif and the SNORD102's ability to interact with proteins involved in the regulation of gene expression make it a likely candidate for inhibitors that target proteins involved in the regulation of gene expression.

One class of small molecule inhibitors that have been shown to be effective in inhibiting the activity of proteins involved in the regulation of gene expression is called chiral molecules. Chiral molecules are molecules that have a left and right stereotype, which are mirror images of each other . These molecules can bind to a specific protein with high affinity, but not to its mirror image.

The development of chiral molecules as potential drug targets has been revolutionized by the use of virtual screening techniques, which allow researchers to identify and test potential binding partners for a protein. By using these techniques, researchers have been able to identify a large number of potential binding partners for various proteins involved in the regulation of gene expression.

SNORD102 has been shown to be a good candidate for a chiral small molecule inhibitor. The CCDN motif and the SNORD102's ability to interact with proteins involved in the regulation of gene expression make it likely to have a unique binding mode that is specific to these proteins. Additionally, the stereochemistry of SNORD102 allows for the production of both enantiomers, which are mirror images of each other,

Protein Name: Small Nucleolar RNA, C/D Box 102

The "SNORD102 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNORD102 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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