Target Name: SNORD115-7
NCBI ID: G100033444
Review Report on SNORD115-7 Target / Biomarker Content of Review Report on SNORD115-7 Target / Biomarker
Other Name(s): HBII-52-7 | Small nucleolar RNA, C/D box 115-7 | small nucleolar RNA, C/D box 115-7

Understanding SNORD115-7: A Potential Disease Drug Target or Biomarker

Genetic research has brought to light numerous small nucleolar RNAs (snoRNAs) with substantial implications for human health. Among these snoRNAs, SNORD115-7 has garnered significant attention due to its potential role as a disease drug target or biomarker. In this article, we delve into the intricacies of SNORD115-7, exploring its functions, associated diseases, and the potential it holds for therapeutic interventions.

The Role of SnoRNAs

SnoRNAs 鈥? small, non-coding RNA molecules 鈥? have been recognized for their crucial role in guiding and modifying ribosomal RNA (rRNA), mainly by methylating or pseudouridylating specific sites. By facilitating these modifications, snoRNAs impact ribosome assembly and enhance protein synthesis, making them essential for cellular processes. Though numerous snoRNAs have been identified, their functions and regulatory mechanisms remain, in large part, elusive.

Introduction to SNORD115-7

SNORD115-7, also known as SNORD115C, is part of a larger cluster of orphan snoRNAs on the human chromosome region 15q11-q13. Researchers have identified several SNORD115-7 isoforms, most notably SNORD115-7a and SNORD115-7b. These isoforms primarily differ in their sequences, indicating potential variations in their functions and interactions within cellular pathways.

Implications in Neurodevelopmental Disorders

Research has recognized a strong association between SNORD115-7 and neurodevelopmental disorders, particularly Prader-Willi syndrome (PWS) and Angelman syndrome (AS). Both PWS and AS are genetic disorders caused by genetic abnormalities in the same region of chromosome 15, leading to the loss of various snoRNAs, including SNORD115-7. The absence of SNORD115-7 has been correlated with specific features characteristic of PWS and AS, such as intellectual disability, motor impairments, and behavioral abnormalities.

Potential Therapeutic Applications

The discovery of SNORD115-7's involvement in neurodevelopmental disorders has opened doors to potential therapeutic interventions. The restoration of SNORD115-7 expression, either by introducing exogenous snoRNA or through gene therapy, holds promise for mitigating some of the symptoms associated with PWS and AS.

Development of Disease Biomarkers

SNORD115-7's unique expression patterns and association with neurodevelopmental disorders provide an excellent platform for biomarker development. By analyzing SNORD115-7 levels in various biological samples, such as blood, urine, or cerebrospinal fluid, researchers can potentially identify individuals at risk of PWS or AS, aiding in early diagnosis and intervention. Moreover, studying the expression patterns of SNORD115-7 could assist in monitoring disease progression or evaluating treatment efficacy.

Research Challenges and Future Directions

Despite the significant strides in understanding SNORD115-7 and its implications, several challenges persist. Investigating the precise molecular mechanisms by which SNORD115-7 modulates neurodevelopmental processes remains an ongoing endeavor. Additionally, obtaining accurate measurements of SNORD115-7 expression levels in different tissues and across individuals necessitates further standardization and quality control in experimental procedures.

Moving forward, comprehensive studies encompassing larger patient cohorts will be crucial in solidifying SNORD115-7's role as a potential drug target or biomarker. By deepening our understanding of SNORD115-7's interactions within neural pathways, researchers may uncover additional therapeutic opportunities for a range of neurodevelopmental disorders beyond PWS and AS.


The emergence of SNORD115-7 as a significant player in neurodevelopmental disorders has sparked immense interest in its potential as a disease drug target or biomarker. With its demonstrated association with PWS and AS, researchers are now striving to unravel the precise mechanisms through which SNORD115-7 influences neurodevelopment. This knowledge holds the key to delivering targeted therapeutic interventions and developing robust biomarkers for accurate diagnosis and monitoring. As we strive towards a deeper understanding of SNORD115-7, we are poised to revolutionize the field of neurodevelopmental disorders and improve the lives of individuals affected by these conditions.

Protein Name: Small Nucleolar RNA, C/D Box 115-7

The "SNORD115-7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNORD115-7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

More Common Targets

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