Target Name: SNORD115-9
NCBI ID: G100033446
Review Report on SNORD115-9 Target / Biomarker Content of Review Report on SNORD115-9 Target / Biomarker
Other Name(s): HBII-52-9 | small nucleolar RNA, C/D box 115-9 | Small nucleolar RNA, C/D box 115-9

Understanding SNORD115-9: A Disease Drug Target or Biomarker

In recent years, researchers have been unraveling the complexity of non-coding RNAs (ncRNAs) and their roles in various biological processes. One such ncRNA of interest is SNORD115-9, a member of the small nucleolar RNA (snoRNA) family. SNORD115-9 has gained attention due to its potential involvement in disease pathogenesis, making it an attractive target for therapeutic intervention or as a biomarker for diagnostic purposes.

The Role of SNORD115-9
SNORD115-9 is a snoRNA that is encoded in the SNORD115 cluster within the Prader-Willi syndrome (PWS) chromosomal region. SnoRNAs are primarily involved in the modification of other RNAs, such as rRNA and snRNA, through base-pairing interactions. While the exact function of SNORD115-9 is still under investigation, it is thought to be involved in the processing or modification of ribosomal RNA. Aberrant expression or dysfunction of SNORD115-9 has been associated with various diseases, warranting further exploration of its potential as a drug target or biomarker.

The Potential as a Disease Drug Target
Numerous studies have implicated SNORD115-9 dysregulation in disease pathogenesis. For instance, in PWS, a complex genetic disorder characterized by intellectual disabilities and compulsive overeating, the SNORD115 cluster is frequently deleted or not expressed. This suggests that the loss of SNORD115-9 may contribute to the development of PWS symptoms. Therefore, targeting SNORD115-9 with therapeutic interventions, such as gene therapy or small molecule compounds, could potentially restore normal RNA processing and ameliorate PWS symptoms.

Moreover, SNORD115-9 has also been implicated in other diseases, such as cancer. Altered expression of SNORD115-9 has been observed in various cancer types, including ovarian, breast, and glioblastoma. In some cases, SNORD115-9 has been shown to promote tumor growth and metastasis by modulating the expression of genes involved in cell proliferation and survival. Hence, targeting SNORD115-9 in cancer cells could provide a novel therapeutic approach to inhibit tumor growth and improve patient outcomes.

Challenges and Opportunities
Although the potential of SNORD115-9 as a disease drug target is promising, several challenges need to be addressed. Firstly, the precise molecular mechanisms through which SNORD115-9 contributes to disease pathogenesis are still not fully understood. Elucidating these underlying mechanisms is crucial for developing effective therapeutic strategies that target SNORD115-9.

Furthermore, delivery methods for therapeutic interventions targeting ncRNAs, including SNORD115-9, need to be optimized. Efficient delivery of therapies to specific target tissues or cells without off-target effects is a significant hurdle. Utilizing advanced delivery systems such as nanoparticle-based technologies or viral vectors may provide promising avenues for overcoming this challenge.

The Potential as a Biomarker
In addition to being a potential drug target, SNORD115-9 also shows promise as a disease biomarker. Biomarkers are measurable indicators that provide information about a specific biological state or condition. SNORD115-9 expression levels have been found to be altered in different diseases, making it a potential diagnostic and prognostic marker.

For example, in neurodevelopmental disorders like autism spectrum disorder (ASD), altered SNORD115-9 expression has been reported. by detecting SNORD115-9 expression levels, clinicians may be able to identify individuals at risk for developing ASD or monitor the progression of the disorder. Similarly, SNORD115-9 has shown promise as a biomarker in certain cancers, where its expression levels correlate with disease aggressiveness and patient prognosis.

SNORD115-9, a member of the snoRNA family, offers exciting potential as both a disease drug target and biomarker. Dysregulation or dysfunction of SNORD115-9 has been implicated in various diseases, making it a promising candidate for therapeutic interventions. Additionally, SNORD115-9 expression levels have demonstrated diagnostic and prognostic value, highlighting its potential as a biomarker for several conditions. However, further research is needed to fully elucidate the mechanisms underlying the role of SNORD115-9 in disease pathogenesis. Addressing the challenges associated with targeting ncRNAs, such as efficient delivery systems, will be crucial for harnessing the full therapeutic potential of SNORD115-9 in the future.

Protein Name: Small Nucleolar RNA, C/D Box 115-9

The "SNORD115-9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNORD115-9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

More Common Targets

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