Target Name: SCARNA27
NCBI ID: G100124533
Review Report on SCARNA27 Target / Biomarker Content of Review Report on SCARNA27 Target / Biomarker
Other Name(s): Small Cajal body-specific RNA 27 | small Cajal body-specific RNA 27

Introduction to SCARNA27, A Potential Drug Target

In the field of biomedicine and drug discovery, identifying potential drug targets and biomarkers is crucial for the development of effective therapies and personalized medicine. One such promising target is SCARNA27, which plays a significant role in various cellular processes. This article aims to provide an in-depth understanding of SCARNA27 as a drug target or biomarker, its biological functions, and its potential implications in the diagnosis and treatment of various diseases.

Understanding SCARNA27

SCARNA27, also known as Small Cajal Body-Specific RNA 27, is a non-coding RNA molecule that is primarily located in the Cajal bodies of the cell nucleus. Cajal bodies are subnuclear organelles involved in the maturation of small nuclear ribonucleoprotein particles (snRNPs) and the modification of small nucleolar RNAs. SCARNA27 is specifically expressed in neural tissue, suggesting its role in neuronal development and function.

Biological Functions

Although SCARNA27's exact biological functions are not yet fully understood, recent studies have shed light on its potential roles in cellular processes. One study demonstrated that SCARNA27 interacts with survival motor neuron (SMN) protein, which is required for the assembly of snRNPs, and contributes to the biogenesis of U2 and U1 snRNPs. These snRNPs are essential for pre-mRNA splicing, a process that enables the removal of intervening sequences (introns) and the joining of exons to form mature mRNA.

Furthermore, SCARNA27 is thought to play a role in the regulation of alternative splicing, a process that enables the generation of multiple mRNA isoforms from a single gene. Dysregulated alternative splicing has been implicated in several diseases, including cancer and neurodegenerative disorders. SCARNA27 may act as a modulator of alternative splicing events, influencing the expression of key genes involved in cellular pathways and disease progression.

Implications in Disease

Given the involvement of SCARNA27 in crucial biological processes, it is not surprising that dysregulation of this molecule has been associated with various diseases. Several studies have shown altered expression levels of SCARNA27 in different types of cancer. For example, in hepatocellular carcinoma, low expression of SCARNA27 was correlated with poor prognosis. In contrast, in lung adenocarcinoma, increased expression of SCARNA27 was shown to be associated with tumor progression and metastasis.

In addition to cancer, SCARNA27 may have implications in neurodegenerative disorders. In spinal muscular atrophy (SMA), a genetic disorder characterized by the loss of motor neurons, reduced levels of SCARNA27 were observed. This reduction in SCARNA27 levels could contribute to the dysfunction of snRNPs assembly and alternative splicing, ultimately leading to SMA pathogenesis. These findings suggest that SCARNA27 could serve as a potential biomarker for disease diagnosis and prognosis.

Targeting SCARNA27 for Therapy

The dysregulation of SCARNA27 in various diseases makes it an intriguing target for therapeutic intervention. Targeting SCARNA27 could potentially restore normal splicing patterns and gene expression, leading to improved disease outcomes. However, the development of SCARNA27-targeted therapies faces several challenges.

One challenge is the efficient delivery of therapeutic agents to the specific cellular compartments where SCARNA27 is active, such as the Cajal bodies. Moreover, the precise mechanisms by which SCARNA27 influences splicing and gene expression are not yet fully understood, making it challenging to design targeted therapies that effectively modulate its functions without interfering with other essential cellular processes.


In summary, SCARNA27 has emerged as a fascinating drug target and biomarker with significant implications in various diseases, particularly cancer and neurodegenerative disorders. Further research is necessary to unravel the precise mechanisms by which SCARNA27 influences cellular processes and to develop targeted therapies that can modulate its functions for therapeutic purposes. As we delve deeper into understanding the world of non-coding RNAs, it becomes increasingly clear that molecules like SCARNA27 hold immense potential for revolutionizing the field of personalized medicine and improving patient outcomes.

Protein Name: Small Cajal Body-specific RNA 27

The "SCARNA27 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SCARNA27 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

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