GATC: A Potential Drug Target for Protein Translation, DNA Replication and Cell Signaling
GATC: A Potential Drug Target for Protein Translation, DNA Replication and Cell Signaling
GATC (Glutamyl-tRNA amidotransferase subunit C, transcript variant 1) is a protein that plays a crucial role in the process of translation of RNA into proteins. It is a key enzyme in the transfer of amino acids from the tRNA to the protein chain during the process of translation. GATC is a single-chain protein that contains 156 amino acids. It has a subunit structure, which consists of a catalytic domain and a non-catalytic domain. The non-catalytic domain is responsible for the stability of the protein and for its ability to interact with other proteins.
GATC is a protein that has been identified as a potential drug target. Several studies have shown that GATC is involved in a variety of cellular processes, including cell signaling, DNA replication, and protein translation. In addition, GATC has been shown to play a role in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.
One of the potential reasons for the potential drug targeting of GATC is its involvement in the regulation of protein translation. GATC is known to play a role in the initiation of the translation process by helping to establish a positive gradient of amino acids along the mRNA. This gradient is essential for the efficient translation of proteins into the cell.
In addition, GATC is also involved in the regulation of protein stability. Studies have shown that GATC plays a role in the stability of the protein and that its levels are regulated by several factors, including the concentration of amino acids, the temperature, and the pH.
Another potential drug target for GATC is its involvement in the regulation of DNA replication. GATC has been shown to play a role in the regulation of DNA replication in various cell types, including cancer cells. In addition, GATC has been shown to interact with the protein p53, which is a well-known regulator of DNA replication. This suggests that GATC may be involved in the regulation of DNA replication and that its levels may be regulated by this protein.
In addition to its role in protein translation and DNA replication, GATC is also involved in the regulation of several other cellular processes. For example, GATC has been shown to play a role in the regulation of cell signaling, and it has been shown to interact with several signaling proteins, including T cell factor-4 (TGF-4) and transforming growth factor-尾1 (TGF-β1).
GATC is also involved in the regulation of protein synthesis and may be a potential drug target for several diseases. Studies have shown that GATC plays a role in the regulation of protein synthesis and that its levels are regulated by several factors, including the concentration of amino acids, the temperature, and the pH. In addition, GATC has been shown to interact with several proteins that are involved in protein synthesis, including the protein tyrosine phosphatase (PTP) and the protein serine/threonine kinase (STK).
In addition to its role in protein synthesis, GATC is also involved in the regulation of several other cellular processes. For example, GATC has been shown to play a role in the regulation of cell adhesion, and it has been shown to interact with several adhesion molecules, including cadherin and E-cadherin.
GATC is also involved in the regulation of the immune response and has been shown to play a role in the regulation of T cell development and activation. Studies have shown that GATC plays a role in the regulation of T cell receptor (TCR) function and that its levels are regulated by several factors, including the concentration of amino acids, the temperature, and the pH.
In addition to its role in T cell development and activation, GATC is also involved in the regulation of several other cellular processes. For example, GATC has been shown to play
Protein Name: Glutamyl-tRNA Amidotransferase Subunit C
Functions: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
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More Common Targets
GATD1 | GATD1-DT | GATD3 | GATM | GATOR1 Complex | GAU1 | GBA1 | GBA2 | GBA3 | GBAP1 | GBE1 | GBF1 | GBGT1 | GBP1 | GBP1P1 | GBP2 | GBP3 | GBP4 | GBP5 | GBP6 | GBP7 | GBX1 | GBX2 | GC | GCA | GCAT | GCC1 | GCC2 | GCC2-AS1 | GCDH | GCFC2 | GCG | GCGR | GCH1 | GCHFR | GCK | GCKR | GCLC | GCLM | GCM1 | GCM2 | GCN1 | GCNA | GCNT1 | GCNT1P3 | GCNT2 | GCNT3 | GCNT4 | GCNT7 | GCOM1 | GCSAM | GCSAML | GCSAML-AS1 | GCSH | GCSHP3 | GCSIR | GDA | GDAP1 | GDAP1L1 | GDAP2 | GDE1 | GDF1 | GDF10 | GDF11 | GDF15 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDI1 | GDI2 | GDI2P1 | GDNF | GDNF Family Receptor alpha | GDNF-AS1 | GDPD1 | GDPD2 | GDPD3 | GDPD4 | GDPD5 | GDPGP1 | GEM | GEMIN2 | GEMIN4 | GEMIN5 | GEMIN6 | GEMIN7 | GEMIN8 | GEMIN8P1 | GEMIN8P4 | GEN1 | general transcription factor IIF (TFIIF) | General transcription factor IIH | Geranylgeranyl transferase | Geranylgeranyl transferase type-1 | GET1 | GET3 | GET4
