GDF15: A Potential Drug Target and Biomarker (G9518)

Target Name: GDF15

NCBI ID: G9518

GDF15

GDF15: A Potential Drug Target and Biomarker

GDF15 (Macrophage inhibitory cytokine-1) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, and gastrointestinal tract. It is a cytokine that is known to play a role in the regulation of inflammation and immune responses . recent studies have suggested that GDF15 may have potential as a drug target or biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of GDF15 is its ability to inhibit the activity of macrophages, which are a type of white blood cell that play a critical role in the immune response. Macrophages are known to play a role in the development and progression of a variety of diseases, including cancer, and they are often increased in the blood of people with these conditions. By inhibiting the activity of macrophages, GDF15 may have the potential to be a useful drug or biomarker for the treatment of these diseases.

GDF15 is also known to play a role in the regulation of cell death, which is an important process that helps cells adapt to changing conditions in the body. In diseases such as cancer, cells often undergo a process of programmed cell death, known as apoptosis , in order to prevent the growth of cancer cells. By inhibiting the activity of macrophages, which are known to play a role in the execution of apoptosis, GDF15 may have the potential to be a useful drug or biomarker for the treatment of cancer.

Another potential function of GDF15 is its ability to regulate the activity of immune cells, which are responsible for fighting off foreign invaders and maintaining the health of the body. In diseases such as autoimmune disorders, the immune system may become activated and cause inflammation and damage to the body's tissues. By inhibiting the activity of macrophages, which are known to play a role in the execution of immune responses, GDF15 may have the potential to be a useful drug or biomarker for the treatment of autoimmune disorders.

In addition to its potential therapeutic functions, GDF15 has also been shown to have potential as a biomarker in various diseases. For example, studies have shown that GDF15 levels are increased in the blood of people with multiple sclerosis, a neurodegenerative disease. Additionally, GDF15 has been shown to be decreased in the blood of people with cancer, which may indicate that it may be a useful biomarker for the detection of this disease.

GDF15 is also a potential drug target, as several studies have shown that it is able to interact with several different signaling pathways. For example, GDF15 has been shown to interact with the PD-L1 pathway, which is involved in the regulation of immune responses . Additionally, GDF15 has been shown to interact with the NF-kappa-B pathway, which is involved in the regulation of inflammation and immune responses. These interactions may have the potential to create new targets for the development of drugs.

In conclusion, GDF15 is a protein that is known to play a number of important roles in the regulation of inflammation and immune responses. Its ability to inhibit the activity of macrophages and regulate the execution of apoptosis, as well as its potential as a drug target and biomarker, make it an attractive candidate for further research. Further studies are needed to fully understand the functions of GDF15 and its potential as a therapeutic agent.

Protein Name: Growth Differentiation Factor 15

Functions: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity)

The "GDF15 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GDF15 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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