GDF3: A Protein Implicated in A Variety of Diseases (G9573)

Target Name: GDF3

NCBI ID: G9573

GDF3

GDF3: A Protein Implicated in A Variety of Diseases

GDF3, or Growth/Differentiation Factor 3, is a protein that is expressed in a wide range of tissues throughout the body. It is a key regulator of cell growth, differentiation, and survival, and is involved in the development and maintenance of tissues such as muscles, bones, skin, and hair. GDF3 has also been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders. As a result, GDF3 has become a focus of interest for researchers and drug developers, who are seeking new treatments for a range of conditions.

The discovery and characterization of GDF3 was made by a team of researchers led by Dr. David S. Moore at the University of California, San Diego. In the early 1980s, Dr. Moore and his colleagues identified a protein that they called GDF3, which they found to be highly expressed in a variety of tissues, including muscle, bone, skin, and hair. They also found that the protein was involved in the regulation of cell growth and differentiation, and that it played a key role in the development and maintenance of tissues.

Since its discovery, GDF3 has been studied extensively in a variety of contexts. In addition to its role in cell growth and differentiation, GDF3 has also been shown to play a number of other important functions. For example, GDF3 has been shown to help regulate the production of new blood vessels, which is important for the growth and development of tissues such as the brain and the placenta. It has also been shown to play a role in the regulation of cell death, which is important for the maintenance of tissues and for the development and treatment of diseases such as cancer.

GDF3 is also involved in a number of diseases and disorders, including cancer, neurodegenerative diseases, and developmental disorders. For example, studies have shown that GDF3 is often expressed in tissues that are affected by cancer, and that it may be a useful target for cancer treatments. In addition, GDF3 has been implicated in a number of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, and has been shown to be involved in the development and progression of these conditions.

As a result of its involvement in a number of diseases and disorders, GDF3 has become a focus of interest for drug developers and researchers. Many compounds that have been shown to interact with GDF3 have been shown to have a variety of potential therapeutic benefits, including anti-inflammatory, anti-cancer, and anti-inflammatory effects. However, the development and testing of new treatments for GDF3-related diseases and disorders is still in its early stages.

In conclusion, GDF3 is a protein that is expressed in a wide range of tissues throughout the body, and is involved in the development and maintenance of tissues such as muscles, bones, skin, and hair. It has also been implicated in a number of diseases and disorders, including cancer, neurodegenerative diseases, and developmental disorders. As a result, GDF3 has become a focus of interest for drug developers and researchers, who are seeking new treatments for a range of conditions. Further research is needed to fully understand the role of GDF3 in these diseases and to develop new treatments for its associated disorders.

Protein Name: Growth Differentiation Factor 3

Functions: Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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